University of Kentucky College of Agriculture
 
 
 
GuiliangTang

Guiliang Tang

This person is no longer active in Plant and Soil Sciences. This is an archive record.

Faculty

 

Directions to University of Kentucky, Lexington, KYUniversity of Kentucky, PSS
Campus LocationKTRDC
1401 University Drive (Office:117C)
Lexington, KY 40546-0236
Phone(859) 257-1594
Fax(859) 323-1077
Emailgtang2@uky.edu

 

MOVING NOTICE

Dear Friends: I moved to the Department of Biological Sciences at the Michigan Technological University (MTU) in November 2011. Please contact me by email (gtang1@mtu.edu) or phone (906-487-2164) for any activity. Welcome you to visit MTU at the Michigan’s Upper Peninsula (U. P.), where you can find the moose!

SPECIALTY

Gene Silencing and Natural Products

EDUCATION

Ph.D., Plant Biochemistry, The Weizmann Institute of Sciences, Rehovot, Israel, 2001

M.S., Crop Breeding, Anhui Agricultural University, Hefei, China, 1991

B.S., Agronomy, Anhui Agricultural University, Hefei, China, 1983

RESEARCH  INTERESTS

My research interests focus on: 1) Understanding the basic mechanism of RNAi and miRNA pathways, 2) Understanding the roles of miRNAs in plant development and abiotic stresses, and 3) Developing tools for functional genomics and gene discovery in plants. For the mechanism of RNAi and miRNA, we are using plant and Drosophila in vitro systems to study how small RNAs are interacting with cellular proteins to form active RNA-protein complexes to regulate mRNA stability and translation. For the roles of miRNAs in plant development and abiotic stress, we are using miRNA profiling technology and technologies of overexpressing or suppressing miRNA expression in plants. For development of functional genomic tools or gene discovery, we are using miRNA vector to silence single gene or multiple genes in plants, target mimicry to block miRNA function, and genome-wide random RNAi for gene discoveries.

PROFESSIONAL EXPERIENCE

2010-present     Associate Editor of BMC Plant Biology

2011-present     Associate Professor, Department of Plant and Soil Sciences & KTRDC, University of Kentucky, Lexington, KY
2005-2011        Assistant Professor, Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY

2001-2005        Postdoctoral Research Fellow, Department of Biochemistry and Molecular Biology at the University of Massachusetts Medical School, Worcester, MA

1991-1995        Assistant Professor of Plant Physiology, College of Life Science, Anhui Agricultural University, Hefei, China

1983-1988        Research Assistant, Guichi Agricutural Research Center, Anhui, China

TANG LAB WEBSITE

http://www.uky.edu/%7Egtang2/Tang-welcome.html

 

 

This person page last updated on 2012-02-23



Research/Teaching Publications

    Books and Book Chapters

    Xiaoqing Tang, Xiaohu Tang, Jozsef Gal, Natasha Kyprianou, Haining Zhu, and Guiliang Tang 2011. Detection of microRNAs in prostate cancer cells by microRNA array, “MicroRNA in Development: Methods and Protocols” edited by Tamas Dalmay, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, HUMANA PRESS (In press)
    Jia, X., V. Mendu, and G. Tang. 2010. An array platform for identification of stressresponsive miRNAs in plants. pp. 253-69. IN: R. Sunkar, ed. Plant Stress Tolerance−Methods and Protocols, vol. 639 in Methods in Molecular Biology. Humana Press, New York.
    Lewis, R.L., V. Mendu, D.H. McNear, and G. Tang. 2010. Role of micro-RNAs in plant abiotic stress. Chapter 6, pp. 357-372. IN: S. M. Jain and D.S. Brar, ed. Molecular Techniques for Crop Improvement, Second Edition. Springer, Cambridge, MA.
    Authors in PSS Dept.: Guiliang Tang Dave McNear
    Xiaoyun Jian, Venugopal Mendu, and Guiliang Tang 2010. An array platform for identification of stress-responsive miRNAs in plants. "Methods in Molecular Biology; Plant Stress Tolerance- Methods and Protocols" edited by Ramanjulu Sunkar, Oklohoma State University, Stillwater, OK, USA. HUMANA PRESS (In press) Publication URL
    Ricky Lewis, Venugopal Mendu, David McNear, and Guiliang Tang. 2009. Roles of microRNAs in Plant Abiotic Stress. Molecular Techniques in Crop Improvement. 2nd Edition, edited by S. Mohan Jain and D.S. Brar. Springer Netherlands, pp 357-372. Publication URL
    Authors in PSS Dept.: Guiliang Tang Dave McNear
    Tang, G., Xiang, Y., Kang, Z. Mendu, V., Tang, X., Jia, X., Chen, Q., and Tang, X. 2008. Small RNA technologies: siRNA, miRNA, antagomiR, target mimicry, miRNA sponge and miRNA profiling. S.-Y. Ying (ed.) Current Perspectives in microRNAs (miRNA),© Springer Science + Business Media B.V. 2008 Publication URL
    Wang-Xia Wang, Peter Nelson, and Guiliang Tang 2008. RNA Interference, mechanisms and proteins involved in. Wiley Encyclopedia of Chemical Biology. Publication URL
    Wang, W., Gaffney, B., Hunt, A.G., and Tang, G. 2007. microRNAs and Plant Development. Encyclopedia of Life Sciences Publication URL
    Authors in PSS Dept.: Guiliang Tang Arthur Hunt
    Xiang, Y. and Tang, G. 2006. RISC Biology, "microRNA: Biology, Function and Expression" edited by Clarke, N.J and Sanseau, P, DNA Press. pp 29-57. Publication URL
    Tang, G. and Zamore, P.D. 2004. Biochemical dissection of RNA silencing in plants, "Methods in Molecular Biology; mRNA Processing and Metabolism- Methods and Protocols" edited by Daniel R. Schoenberg , Ohio State University, Columbus, OH, USA. HUMANA PRESS ,Vol. 257: 223-243 Publication URL
    Miron, D., Tang, G., Karchi, H., Schupper, A., Ben-Yaacob, S. and Galili,G. 1998. Regulation of Lysine Catabolism in Plants. Plant Biotechnology and In Vitro Biology in the 21st Century, Kluwer Academic Publishers.311-314.

    Refereed Journal Articles

    Dianwei Han, Jun Zhang, and Guiliang Tang 2011. MicroRNAfold: pre-microRNA secondary structure prediction based on Modified NCM model with thermodynamics-based scoring strategy. International Journal of Data Mining and Bioinformatics (In press)
    Lijuan Ji, Xigang Liu, Jun Yan, Wenming Wang, Rae Eden Yumul, Yu Ju Kim, Thanh Theresa Dinh, Jun Liu, Xia Cui, Binglian Zheng, Manu Agarwal, Chunyan Liu, Xiaofeng Cao, Guiliang Tang, and Xuemei Chen* 2011. ARGONAUTE10 and ARGONAUTE1 Regulate the Termination of Floral Stem Cells through Two microRNAs in Arabidopsis. PLOS Genetics (In press)
    Xiaoyun Jia and Guiliang Tang 2011. MicroRNA-mediated DNA methylation in plants. Frontiers in Biology (In press)
    Gu, M., K. Xu, A. Chen, Y. Zhu, G. Tang, and G. Xu. 2010. Expression analysis suggests potential roles of microRNAs for phosphate and arbuscular mycorrhizal signaling in Solanum lycopersicum. Physiologia of Planta 138(2):226-37.
    Guiliang Tang 2010. Plant microRNAs: An insight into their gene structures and evolution. Seminars in Cell and Developmental Biology 21:782-789. Publication URL
    Mian Gu, Ke Xu, Aiqun Chen, Yiyong Zhu, Guiliang Tang, and Guohua Xu 2010. Expression Analysis Suggests Potential Roles of microRNAs for Phosphate and Arbuscular Mycorrhizal Signaling in Solanum lycopersicum. Physiol Plant.138(2):226-37. Publication URL
    Tang, G. 2010. Plant microRNA: An insight into the gene structure and evolution. Seminars in Cell and Developmental Biology 21:782-789.
    Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT 2010. MiR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease. Am J Pathol. 177: 334-345 Publication URL
    Jia,X., Ren, L., Chen, Q., Li, R., and Tang, G. 2009. UV-B responsive microRNAs in Populus tremula. J. of Plant Physiology 166: 2046-2057. Publication URL
    Jia, X., Wang,W., Ren,L., Chen, Q., Mendu, V., Willcut, B., Dinkins, D., Tang,X., and Tang, G. 2009. Differential and dynamic regulation of miR398 and its targets in response to ABA and salt stress in Populus tremula and Arabidopsis thaliana. Plant Molecular Biology 71: 51-59 Publication URL
    Authors in PSS Dept.: Guiliang Tang Randy Dinkins
    Tang, X., Muniappan, L., Tang, G., and Ozcan, S. 2009. Identification of glucose-regulated miRNAs from pancreatic beta cells reveals a role for miR-30d in insulin transcription RNA. 15:287-293. Publication URL
    Nelson, P., Wang, W., Wilfred, B., Tang, G. 2008. Technical variables in high-throughput miRNA expression profiling: Much work remains to be done. BBA-Gene Regulatory Mechanisms Special Issue: MicroRNA 1779: 758-765 Publication URL
    Nelson, P.T., W.-X. Wang, B.R. Wilfred, and G. Tang. 2008. Technical variables in high-throughput miRNA expression profiling: Much work remains to be done. BBA-Gene Regulatory Mechanisms 1779:758-765.
    Tang, G. 2008. MicroRNAs: An exciting and open field calls for extensive study from initial and established investigators. BBA-Gene Regulatory Mechanisms 1779:653-654.
    Tang, G., X. Tang, V. Mendu, X. Tang, X. Jia, Q.-J. Chen, and L. He. 2008. Mendu, X. Tang, X. Jia, Q.-J. Chen, and L. He. The art of microRNA: Various strategies leading to gene silencing via an ancient pathway. BBA-Gene Regulatory Mechanisms 1779:655-662.
    Tang, G., Y. Xiang, Z. Kang, V. Mendu, X. Tang, X. Jia, Q.-J. Chen, and X. Tang. 2008. Small RNA technologies: siRNA, miRNA, antagomiR, target mimicry, miRNA sponge, and miRNA profiling. pp. 17-33. IN: S.-Y. Ying, ed. Current Perspectives in MicroRNAs. Springer, the Netherlands.
    Tang, X., G. Tang, and S. Ozcan. 2008. Role of microRNAs in diabetes. BBA-Gene Regulatory Mechanisms 1779:697-701.
    Tang, X., Tang, G., and Ozcan, S. 2008. Role of MicroRNAs in Diabetes. BBA-Gene Regulatory Mechanisms 1779: 697-701 Publication URL
    Tang,G., Tang, X., Mendu, V., Tang, X., Jia, X., Chen, Q., and He, L. 2008. The art of microRNA: various strategies leading to gene silencing via an ancient pathway. BBA-Gene Regulatory Mechanisms 1779: 655-662 Publication URL
    Wang, W.-X., B.W. Rajeev, A. Stromberg, N. Ren, G. Tang, Q. Huang, I. Rigoutsos, and P.T. Nelson. 2008. The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of BACE1. Journal of Neuroscience 28(5):1213-1223.
    Wang-Xia Wang, Bernard W. Rajeev, Arnold Stromberg, Na Ren, Guiliang Tang, Qingwei Huang, Isidore Rigoutsos, and Peter T. Nelson. 2008. The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of BACE1. Journal of Neuroscience,28(5): 1213-1223. Publication URL
    Tang, G., G. Galili, and X. Zhuang. 2007. RNAi and microRNA: Breakthrough technologies for the improvement of plant nutritional value and metabolic engineering. Metabolomics 3:357-369.
    Tang, G., Galili, G., and Zhuang, X. 2007. RNAi and microRNA: Breakthrough technologies for the improvement of plant nutritional value and metabolic engineering. Metabolomics. 3: 357-369 Publication URL
    Tang, X., Gal, J., Zhuang, Z., Wang, W., Zhu, H., and Tang, G. 2007. A simple array platform for microRNA analysis and its application in mouse tissues. RNA.13: 1803-1822 Publication URL
    Tang, X., J. Gal, X. Zhuang, W. Wang, H. Zhu, and G. Tang. 2007. A simple array platform for microRNA analysis and its application in mouse tissues. RNA 13:1803-1822.
    Wang, W.-X., B. Gaffney, A.G. Hunt, and G. Tang. 2007. MicroRNAs (miRNAs) and plant development. Encyclopedia of Life Sciences, John Wiley & Sons Ltd. Published online: www.els.net. doi: 10.1002/9780470015902. a0020106.
    Authors in PSS Dept.: Guiliang Tang Arthur Hunt
    Stepansky, A., Yao, Y., Tang, G., Galili, G. 2005. Regulation of lysine catabolism in Arabidopsis through concertedly-regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus. J. Exp. Bot. 56: 525-536
    Tang, G. 2005. siRNA and miRNA: an insight into RISCs. Trends in Biochemical Sciences 30: 106-114. Publication URL
    Mallory, A.C., Reinhart, B.J., Rhoades M.W., Tang, G., Zamore, P.D., Barton, M.K., and Bartel, D.P. 2004. MiRNA control of PHABULOSA during leaf development: importance of pairing to the miRNA 5´ region. EMBO J 23: 3356-3364 Publication URL
    Tang, G. and Galili, G. 2004. Using RNAi to improve plant nutritional value: from mechanism to application. Trends in Biotechnology 22: 463-469. Publication URL
    Haley, B. Tang, G. and Zamore P.D. 2003. In Vitro Analysis of RNA interference in Drosophila melanogaster. Methods 30:330-336 Publication URL
    Tang, G., B.J. Reinhart, D.P. Bartel, P.D. Zamore. 2003. A biochemical framework for RNA silencing in plants. Genes Dev 17: 49-63 Publication URL
    Tang, G., Zhu, X., Gakiere, B., Levanony, H., Kahana, A. and Galili, G. 2002. The bifunctional LKR/SDH locus of plants also encodes a highly active monofunctional lysine-ketoglutarate reductase using a polyadenylation signal located within intron. Plant Physiol.130:147
    Zhu, X, Tang, G. and Galili G. 2002. The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains. J Biol Chem. 277: 49655-49661
    Galili G, Tang G, Zhu X, Karchi H, Miron D, Gakiere B, and Stepansky A. 2001. Molecular genetic dissection and potential manipulation of lysine metabolism in seeds. J Plant Physiol.158: 515-520
    Galili, G., Tang, G., Zhu, X. and Gakiere, B. 2001. Lysine catabolism: a stress and development super-regulated metabolic pathway. Current Opinion in Plant Biology, 4: 261- 266 Publication URL
    Zhu, X., Tang, G., Granier, F., Boucher, D. and Galili, G. 2001. A T-DNA insertion knockout of the bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase gene elevates lysine levels in Arabidopsis seeds. Plant Physiol.126:1539-1545
    Galili, G., Tang, G., Zhu, X., Amir, R., Levanony, H., Shy, G. and Elliot M. Herman. 2000. Plant seeds: an exciting model system for dissecting molecular and cellular regulation of metabolic processes. Isr. J. Plant Sci. 48: 181-187
    Tang, G., Zhu, X., Tang, X. and Galili, G. 2000. A novel composite locus encoding simultaneously two polypeptides with metabolically related but distinct functions in lysine catabolism. Plant J., 23: 195-203 Publication URL
    Zhu, X., Tang, G. and Galili, G. 2000. The catabolic function of the a-amino adipic acid pathway in plants is correlated with unidirectional activity of lysine-ketoglutarate reductase, but not saccharopine dehydrogenase. Biochemical J., 351: 215-220
    Zhu, X., Tang, G. and Galili, G. 2000. Characterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite AtLKR/SDH locus of Arabidopsis. Plant Physiol.124: 1363-1371
    Tang, G., Miron, D., Zhu-Shimoni, JX., and Galili, G. 1997. Regulation of Lysine Catabolism through Lysine-Ketoglutarate Reductase and Saccharopine Dehydrogenase in Arabidopsis. The Plant Cell, 9:1305-1316 Publication URL
    Tang, G., Zhu-Shimoni,J.X., Amir,R., Zchori,I.B. and Galili,G. 1997. Cloning and expression of an Arabidopsis thaliana cDNA encoding a monofunctional aspartate kinase homologous to the lysine-sensitive enzyme of Escherichia coli. Plant Mol. Biol. 34: 287-294