University of Kentucky College of Agriculture

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Peter D. Nagy

Peter D. Nagy, Ph.D.

Department of Plant Pathology
University of Kentucky
221 Plant Science Building
Lexington, KY 40546-0312

telephone: (859) 218-0726
fax: (859) 323-1961

Nagy Lab


Ph.D. in Plant Protection, 1990, Hungarian Academy of Sciences, Institute of Plant Protection, Budapest
B.Sc. and M.S. in Plant Protection, 1985, Agricultural University of Keszthely, Hungary

Focus Research
  • Virus replication: We use Tombus viruses, small model RNA viruses of plants, to identify the viral and host players in replication and to unravel the mechanism of virus replication.
  • Virus recombination: To understand the mechanism of virus evolution

  • PPA 671, Advanced Plant Virology



Employment Highlights
  • Professor, University of Kentucky, 2007 to present
  • Associate Professor, University of Kentucky, 2003-2007
  • Assistant Professor, University of Kentucky, 1999-2003
  • Research Associate, University of Massachussetts, 1996-1998
  • Research Associate, Northern Illinois Universtiy, 1990-1995
  • Postdoctoral Fellow, University of Bari, Italy, 1990



Awards, Recognition, Service 2008 to present
  • Bobby Pass Excellence in Grantmanship Award, 2013
  • Smith fellow lecturer, University of British Columbia, Vancouver, Canada, 2011
  • Breakthrough paper on virus replication (Wang, and Nagy, P. D.) was selected in the “SPOTLIGHT” by Journal of Virology, the leading journal in the field of virology, 2009
Recent Research Publications 2012 to present (a more complete list can be found on the Nagy Lab pages)
  • Xu, K., and P. D. Nagy. 2015. RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes. Proc Natl Acad Sci U S A 112:E1782-E1791.
  • Tian, M., Z. Sasvari, P. A. Gonzalez, G. Friso, E. Rowland, X. M. Liu, K. J. van Wijk, P. D. Nagy, and D. F. Klessig. 2015. Salicylic Acid Inhibits the Replication of Tomato bushy stunt virus by Directly Targeting a Host Component in the Replication Complex. Mol Plant Microbe Interact 28:379-86.
  • Prasanth, K. R., D. Barajas, and P. D. Nagy. 2015. The Proteasomal Rpn11 Metalloprotease Suppresses Tombusvirus RNA Recombination and Promotes Viral Replication via Facilitating Assembly of the Viral Replicase Complex. J Virol 89:2750-63.
  • Pogany, J., and P. D. Nagy. 2015. Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro. J Virol 89:5714-23.
  • Nagy, P. D. 2015. Viral Sensing of the Subcellular Environment Regulates the Assembly of New Viral Replicase Complexes during the Course of Infection. J Virol 89:5196-5199.
  • Chuang, C., K. R. Prasanth, and P. D. Nagy. 2015. Coordinated Function of Cellular DEAD-Box Helicases in Suppression of Viral RNA Recombination and Maintenance of Viral Genome Integrity. PLoS Pathog 11:e1004680.
  • Barajas, D., N. Kovalev, J. Qin, and P. D. Nagy. 2015. Novel Mechanism of Regulation of Tomato Bushy Stunt Virus Replication by Cellular WW-Domain Proteins. J Virol 89:2064-79.
  • Xu, K., and P. D. Nagy. 2014. Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Curr Opin Virol 9C:119-126.
  • Xu, K., J. Y. Lin, and P. D. Nagy. 2014. The hop-like stress-induced protein 1 cochaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication. J Virol 88:9361-78.
  • Sasvari, Z., P. Alatriste Gonzalez, and P. D. Nagy. 2014. Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors. Front Plant Sci 5:383.
  • Nagy, P. D., J. Pogany, and J. Y. Lin. 2014. How yeast can be used as a genetic platform to explore virus-host interactions: from 'omics' to functional studies. Trends Microbiol 22:309-316.
  • Li, Z., P. A. Gonzalez, Z. Sasvari, T. G. Kinzy, and P. D. Nagy. 2014. Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Virology 448C:43-54.
  • Kovalev, N., J. Pogany, and P. D. Nagy. 2014. Template role of double-stranded RNA in tombusvirus replication. J Virol 88:5638-51.
  • Kovalev, N., and P. D. Nagy. 2014. The Expanding Functions of Cellular Helicases: The Tombusvirus RNA Replication Enhancer Co-opts the Plant eIF4AIII-Like AtRH2 and the DDX5-Like AtRH5 DEAD-Box RNA Helicases to Promote Viral Asymmetric RNA Replication. PLoS Pathog 10:e1004051.
  • Chuang, C., D. Barajas, J. Qin, and P. D. Nagy. 2014. Inactivation of the Host Lipin Gene Accelerates RNA Virus Replication through Viral Exploitation of the Expanded Endoplasmic Reticulum Membrane. PLoS Pathog 10:e1003944.
  • Barajas, D., K. Xu, M. Sharma, C. Y. Wu, and P. D. Nagy. 2014. Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology 471-473C:72-80.
  • Barajas, D., K. Xu, I. F. de Castro Martin, Z. Sasvari, F. Brandizzi, C. Risco, and P. D. Nagy. 2014. Co-opted Oxysterol-Binding ORP and VAP Proteins Channel Sterols to RNA Virus Replication Sites via Membrane Contact Sites. PLoS Pathog 10:e1004388.
  • Barajas, D., I. F. Martin, J. Pogany, C. Risco, and P. D. Nagy. 2014. Noncanonical Role for the Host Vps4 AAA+ ATPase ESCRT Protein in the Formation of Tomato Bushy Stunt Virus Replicase. PLoS Pathog 10:e1004087.
  • Shah Nawaz-Ul-Rehman, M., K. Reddisiva Prasanth, J. Baker, and P. D. Nagy. 2013. Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants. Methods 59:207-16.
  • Sasvari, Z., N. Kovalev, and P. D. Nagy. 2013. The GEF1 Proton-Chloride Exchanger Affects Tombusvirus Replication via Regulation of Copper Metabolism in Yeast. J Virol 87:1800-10.
  • Sasvari, Z., P. A. Gonzalez, R. A. Rachubinski, and P. D. Nagy. 2013. Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein. Virology 447:21-31.
  • Pathak, K. B., Z. Jiang, V. Ochanine, M. Sharma, J. Pogany, and P. D. Nagy. 2013. Characterization of dominant-negative and temperature-sensitive mutants of tombusvirus replication proteins affecting replicase assembly. Virology 437:48-61.
  • Lin, J. Y., and P. D. Nagy. 2013. Identification of Novel Host Factors via Conserved Domain Search: Cns1 Cochaperone Is a Novel Restriction Factor of Tombusvirus Replication in Yeast. J Virol 87:12600-10.
  • Kovalev, N., and P. D. Nagy. 2013. Cyclophilin a binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. J Virol 87:13330-42.
  • Xu, K., T. S. Huang, and P. D. Nagy. 2012. Authentic in vitro replication of two tombusviruses in isolated mitochondrial and endoplasmic reticulum membranes. J Virol 86:12779-94.
  • Shah Nawaz-Ul-Rehman, M., N. Martinez-Ochoa, H. Pascal, Z. Sasvari, C. Herbst, K. Xu, J. Baker, M. Sharma, A. Herbst, and P. D. Nagy. 2012. Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C. J Virol 86:9384-95.
  • Sasvari, Z., and P. D. Nagy. 2012. Identification of small molecule inhibitors of tomato bushy stunt virus replication. Methods Mol Biol 894:345-57.
  • Qin, J., D. Barajas, and P. D. Nagy. 2012. An inhibitory function of WW domain-containing host proteins in RNA virus replication. Virology 426:106-19.
  • Pogany, J., and P. D. Nagy. 2012. p33-Independent Activation of a Truncated p92 RNA-Dependent RNA Polymerase of Tomato Bushy Stunt Virus in Yeast Cell-Free Extract. J Virol 86:12025-38.
  • Pathak, K. B., J. Pogany, K. Xu, K. A. White, and P. D. Nagy. 2012. Defining the Roles of cis-Acting RNA Elements in Tombusvirus Replicase Assembly In Vitro. J Virol 86:156-71.
  • Nagy, P. D., and C. D. Richardson. 2012. Viral replication-in search of the perfect host. Curr Opin Virol.
  • Nagy, P. D., and J. Pogany. 2012. The dependence of viral RNA replication on co-opted host factors. Nature Reviews Microbiology 10:137-149.
  • Nagy, P. D., D. Barajas, and J. Pogany. 2012. Host factors with regulatory roles in tombusvirus replication. Curr Opin Virol 2:685-92.
  • Lin, J. Y., V. Mendu, J. Pogany, J. Qin, and P. D. Nagy. 2012. The TPR Domain in the Host Cyp40-like Cyclophilin Binds to the Viral Replication Protein and Inhibits the Assembly of the Tombusviral Replicase. PLoS Pathog 8:e1002491.
  • Kovalev, N., J. Pogany, and P. D. Nagy. 2012. A Co-Opted DEAD-Box RNA Helicase Enhances Tombusvirus Plus-Strand Synthesis. PLoS Pathog 8:e1002537.
  • Kovalev, N., D. Barajas, and P. D. Nagy. 2012. Similar roles for yeast Dbp2 and Arabidopsis RH20 DEAD-box RNA helicases to Ded1 helicase in tombusvirus plus-strand synthesis. Virology 432:470-84.
  • Barajas, D., and P. D. Nagy. 2012. Expression of dominant-negative mutants to study host factors affecting plant virus infections. Methods Mol Biol 894:359-76.


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