University of Kentucky College of Agriculture

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Peter D. Nagy

Peter D. Nagy, Ph.D.

Department of Plant Pathology
University of Kentucky
221 Plant Science Building
Lexington, KY 40546-0312

telephone: (859) 218-0726
fax: (859) 323-1961

Nagy Lab


Ph.D. in Plant Protection, 1990, Hungarian Academy of Sciences, Institute of Plant Protection, Budapest
B.Sc. and M.S. in Plant Protection, 1985, Agricultural University of Keszthely, Hungary

Focus Research
  • Virus replication: We use Tombus viruses, small model RNA viruses of plants, to identify the viral and host players in replication and to unravel the mechanism of virus replication.
  • Virus recombination: To understand the mechanism of virus evolution

  • PPA 671, Advanced Plant Virology



Employment Highlights
  • Professor, University of Kentucky, 2007 to present
  • Associate Professor, University of Kentucky, 2003-2007
  • Assistant Professor, University of Kentucky, 1999-2003
  • Research Associate, University of Massachussetts, 1996-1998
  • Research Associate, Northern Illinois Universtiy, 1990-1995
  • Postdoctoral Fellow, University of Bari, Italy, 1990



Awards, Recognition, Service 2008 to present
  • Bobby Pass Excellence in Grantmanship Award, 2013
  • Smith fellow lecturer, University of British Columbia, Vancouver, Canada, 2011
  • Breakthrough paper on virus replication (Wang, and Nagy, P. D.) was selected in the “SPOTLIGHT” by Journal of Virology, the leading journal in the field of virology, 2009
Recent Research Publications 2010 to present
  • Barajas D, Martin IFD, Pogany J, Risco C, Nagy PD (2014) Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of tomato bushy stunt virus replicase. PLoS Pathogens 10: 16. doi 10.1371/journal.ppat.1004087
  • Barajas D, Xu K, Martin IFD, Sasvari Z, Brandizzi F, Risco C, Nagy PD (2014) Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites. PLoS Pathogens 10: 18. doi 10.1371/journal.ppat.1004388
  • Barajas D, Xu K, Sharma M, Wu CY, Nagy PD (2014) Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology 471: 72-80. doi 10.1016/j.virol.2014.10.005
  • Chuang CK, Barajas D, Qin J, Nagy PD (2014) Inactivation of the host lipin gene accelerates RNA virus replication through viral exploitation of the expanded endoplasmic reticulum membrane. PLoS Pathogens 10: 15. doi 10.1371/journal.ppat.1003944
  • Kovalev N, Nagy PD (2014) The expanding functions of cellular helicases: the tombusvirus RNA replication enhancer co-opts the plant eIF4AIII-like AtRH2 and the DDX5-iike AtRH5 DEAD-box RNA helicases to promote viral asymmetric RNA replication. PLoS Pathogens 10: 15. doi 10.1371/journal.ppat.1004051
  • Kovalev N, Pogany J, Nagy PD (2014) Template role of double-stranded RNA in tombusvirus replication. Journal of Virology 88: 5638-5651. doi 10.1128/jvi.03842-13
  • Li ZH, Gonzalez PA, Sasvari Z, Kinzy TG, Nagy PD (2014) Methylation of translation elongation factor 1A by the METTL10-like SEEL methyltransferase facilitates tombusvirus replication in yeast and plants. Virology 448: 43-54. doi 10.1016/j.virol.2013.09.012
  • Xu K, Lin JY, Nagy PD (2014) The Hop-Like Stress-Induced Protein 1 Cochaperone Is a Novel Cell-Intrinsic Restriction Factor for Mitochondrial Tombusvirus Replication. Journal of Virology 88: 9361-9378. doi 10.1128/jvi.00561-14
  • Xu K, Nagy PD (2014) Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Current Opinion in Virology 9: 119-126. doi 10.1016/j.coviro.2014.09.015
  • Nagy PD, Pogany J, Lin JY (2014) How yeast can be used as a genetic platform to explore virus-host interactions: from 'omics' to functional studies. Trends in Microbiology 22: 309-316. doi 10.1016/j.tim.2014.02.003
  • Sasvari Z, Alatriste Gonzalez P, Nagy PD (2014) Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors. Frontiers in Plant Science 5: 383. doi 10.3389/fpls.2014.00383
  • Lin JY, Nagy PD (2013) Identification of novel host factors via conserved domain search: Cns1 cochaperone is a novel restriction factor of tombusvirus replication in yeast. Journal of Virology 87: 12600-12610. doi 10.1128/jvi.00196-13
  • Nawaz-ul-Rehman MS, Prasanth KR, Baker J, Nagy PD (2013) Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants. Methods 59: 207-216. doi 10.1016/j.ymeth.2012.11.001
  • Pathak KB, Jiang ZD, Ochanine V, Sharma M, Pogany J, Nagy PD (2013) Characterization of dominant-negative and temperature-sensitive mutants of tombusvirus replication proteins affecting replicase assembly. Virology 437: 48-61. doi 10.1016/j.virol.2012.12.009
  • Sasvari Z, Gonzalez PA, Rachubinski RA, Nagy PD (2013) Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein. Virology 447: 21-31. doi 10.1016/j.virol.2013.07.039
  • Kovalev N, Nagy PD (2013) Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. Journal of Virology 87: 13330-13342. doi 10.1128/jvi.02101-13
  • Sasvari, Z.; Kovalev, N.; Nagy, P.D., The GEF1 Proton-Chloride Exchanger Affects Tombusvirus Replication via Regulation of Copper Metabolism in Yeast. Journal of Virology 2013, 87, 1800-1810. doi: 10.1128/jvi.02003-12
  • Xu, K.; Huang, T.S.; Nagy, P.D., Authentic In Vitro Replication of Two Tombusviruses in Isolated Mitochondrial and Endoplasmic Reticulum Membranes. Journal of Virology 2012, 86, 12779-12794. doi: 10.1128/jvi.00973-12
  • Nagy, P.D.; Richardson, C.D., Viral replication - in search of the perfect host. Current Opinion in Virology 2012, 2, 663-668. doi: 10.1016/j.coviro.2012.11.001
  • Nagy, P.D.; Pogany, J., The dependence of viral RNA replication on co-opted host factors. Nat. Rev. Microbiol. 2012, 10, 137-149. doi: 10.1038/nrmicro2692
  • Nagy, P.D.; Barajas, D.; Pogany, J., Host factors with regulatory roles in tombusvirus replication. Current Opinion in Virology 2012, 2, 691-698. doi: 10.1016/j.coviro.2012.10.004
  • Jaag, H.M.; Pogany, J.; Nagy, P.D., A Host Ca2+/Mn2+ Ion Pump Is a Factor in the Emergence of Viral RNA Recombinants. Cell Host & Microbe 2010, 7, 74-81. doi: 10.1016/j.chom.2009.12.009
  • Jaag, H.M.; Nagy, P.D., The Combined Effect of Environmental and Host Factors on the Emergence of Viral RNA Recombinants. PLoS Pathogens 2010, 6. doi: 10.1371/journal.ppat.1001156
  • Li, Z.H.; Pogany, J.; Tupman, S.; Esposito, A.M.; Kinzy, T.G.; Nagy, P.D., Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis. PLoS Pathogens 2010, 6. doi: 10.1371/journal.ppat.1001175
  • Nagy, P.D.; Pogany, J., Global Genomics and Proteomics Approaches to Identify Host Factors as Targets to Induce Resistance Against Tomato Bushy Stunt Virus. In Natural and Engineered Resistance to Plant Viruses, Pt Ii, Carr, J.P.; Loebenstein, G., Eds. 2010; Vol. 76, pp 123-177. doi: 10.1016/s0065-3527(10)76004-8


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