Immunogenically Active Proteins of Streptococcus equi
Sergey C. Artiushin, Ph.D.
Our laboratory has been systematically characterizing proteins of Streptococcus equi that elicit serum and mucosal antibody responses in horses during recovery from strangles. The goal is to identify proteins expressed by S. equi that participate in protective immune responses and that would be included in a subunit vaccine and useful for immunodiagnosis.
Recent work in our laboratory has resulted in the discovery of 22 novel cell wall, transmembrane and secreted proteins of S. equi that participate in convalescent immune responses. My current research focuses on expression and variability of these proteins in S. equi and S. zooepidemicus strains.
Other research activity within this project centers on novel systems for stimulating mucosal immune responses in the horse. These include Se18.9-antigen fusions and use of attenuated Salmonella typhimurium to present streptococcal peptides to the horse’s immune system.
Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099
Main Office (859) 257-4757
Fax (859) 257-8542