University of Kentucky College of Agriculture, Food & Environment

 

Gluck Center > Directory > Gluck Faculty > Balasuriya, UBR > Curriculum Vitae

CURRICULUM VITAE

Udeni B.R. Balasuriya, BVSc, MS, PhD
ubalasuriya@uky.edu
(859) 218-1124

Professor of Virology
Department of Veterinary Science
M.H. Gluck Equine Research Center
College of Agriculture, Food & Environment
University of Kentucky

Professional Experience

2011 - Present; Professor of Virology, Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington.

2013 - Present; Professor of Virology (Joint Appointment), Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington.

2015 - Present; Professor of Virology (Adjunct Faculty Member), College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee.

2006 - Present; Graduate Faculty (Full Member) for the Veterinary Science Program, Graduate School, University of Kentucky, Lexington.

2005 - 2011; Associate Professor of Virology, Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington.

2001 - 2005; Associate Research Molecular Virologist, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis.

1999 - 2005; Scientific Director and Coordinator, Equine Viral Disease Laboratory, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis.

1997 - 2001; Assistant Research Molecular Virologist, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis.

1996 -1997; Postdoctoral Fellow, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis.

1991 - 1996; Graduate Student/Postgraduate Researcher, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis.

1990 - 1992; Residency training in Diagnostic Veterinary Pathology, Veterinary Medical Teaching Hospital, University of California, Davis.

1989 - 1991; Graduate Student, Department of Pathology, School of Veterinary Medicine, University of California, Davis.

1985 - 1989; Veterinary Research Officer, Veterinary Research Institute, Sri Lanka.

Peer-Reviewed Publications (2010-2015)

#Li, Y., Cook, R. F., Pronost, S., Henney, P. J., Crossley, B. M., Sells, S. F., Goehring, L. S., Lunn, D. P., Cuxson, J., Hartley, C., Gilkerson, J. R., Kirkland, P., Smith, K. L., Laegreid, W., Timoney, P. J., and *Balasuriya, U. B. R. 2015. Genotypic and phylogenetic analyses of the DNA polymerase gene (ORF30) from EHV-1 demonstrate conservation of critical amino acid residues within the Alphaherpesvirinae and suggest a point mutation at position 2254 is not the sole determinant of neurovirulence. Virology (In revision).

#Nam, B., Li, G., Zhenga, Y., Shuck, K. M., Timoney, P. J. and Balasuriya, U. B. R. 2015. Complete genome sequence of noncytopathic bovine virus diarrhea virus-1 (BVDV-1) contaminating high passage RK13 cell line. ASM Genome Announcements (Submitted).

Moeller Jr., R. B., Crossley, B. Li, Y., Pipkin, A., and Balasuriya, U. B. R. 2015. Systemic Equine Herpsvirus-9 in a Grants Zebra (Equus quagga boehmi). J. Vet. Diagn. Invest. (Submitted).

#Lu, Z., Sarkar, S, Zhang, J. and Balasuriya, U. B. R. 2015. Conserved arginine residues in the E protein of equine arteritis virus may play a role in heparin binding Arch. Virol. (Submitted).

#Mondal, S. P., Cook, R. F., Chelvarajan, R. L., Henney, P. J., Timoney, P. J., and Balasuriya, U. B. R. 2015. Development and characterization of a synthetic infectious cDNA clone of the virulent Bucyrus strain of equine arteritis virus expressing mCherry (red fluorescent protein). Arch. Virol. (Under review).

Go, Y. Y., Jung, E., Jeong, Y. E., and Balasuriya, U. B. R. 2015. Complete genome sequencing and phylogenetic analysis of three clinical isolates (serotype 1) and three laboratory strains (serotypes 2, 3, and 4) of dengue virus available in South Korea. Springer Plus (In revision).

#Sarkar, S., Balasuriya, U. B. R., Horohov, D. W., and Chambers, T. M. 2015. The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells. Vet Microbiol. (Published online).

#Pfahl, K., Chung, C. J., Singleton, M. D., Shuck, K. M., Go, Y. Y., Zhang, J., Yun Young Go, Campos, J. R., Adams, E., Adams, D. S., Timoney, P. J., and *Balasuriya, U. B. R. 2015. Further evaluation and validation of a commercially available competitive enzyme linked immunosorbent assay (cELISA) for the detection of antibodies specific to equine arteritis virus (EAV). Vet. Rec. (Under review).

Chung, C. J., Grimm, A. L., Wilson, C. L., Balasuriya, U. B. R., Chung, G., Timoney, P. J., Bandaranayaka-Mudiyanselage, C. B., Lee, S. S., and McGuire, T. C. 2015. Enhanced sensitivity of an antibody competitive blocking enzyme linked immunosorbent assay using equine arteritis virus purified by anion exchange membrane chromatography. J. Vet. Diagn. Invest. (Under review).

#Sarkar, S., Balasuriya, U. B. R., Horohov, D. W., and Chambers, T. M. 2015. EHV-1 suppresses type-I interferon induction in equine endothelial cells. Vet. Immunol. Immunopath. (in press).

*Balasuriya, U. B. R., Beate M. Crossley, B. M., and Timoney, P. J. 2015. A review of traditional and contemporary molecular diagnostic assays for direct and indirect detection of equine herpesvirus-1 in clinical samples (Invited Review). J. Vet. Diagn. Invest. (In press).

van Kasteren, P. B., Knaap, R. C., van den Elzen, P., Snijder, E. J., Balasuriya, U. B. R., van den Born, E., and Kikkert M. 2015. In vivo assessment of arterivirus vaccine improvement by disabling the deubiquitinase activity of equine arteritis virus papain-like protease 2. Vet. Micro. Biol. 178:132-137.

*Balasuriya, U. B. R. 2014. Equine viral arteritis (Invited Review). Vet. Clin. North Am.: Equine Practice (30):543-560.

Holyoak, G. R., Lyman, C. C., and Balasuriya, U. B. R. 2014. Equine viral arteritis – an update. Clinical Theriogenology 6(3): 321-327.

#Campos, J. R., Breheny, P., Araujo, R. R., Troedsson, M. H. T., Squires, E. L., Timoney, P. J., and *Balasuriya, U. B. R. 2014. Evaluation of semen quality of stallions challenged with the Kentucky 84 (KY84) strain of equine arteritis virus (EAV). Theriogenology 82(8):1068-79.

*Balasuriya, U. B. R., Lee, P. Y. A., Tiwari, A., Skillman, A., Nam, B., Chambers, T. M., Tsai, Y. L., Ma, L. J., Yang, P. C., Chung, S., Chang, H. F. G, and Wang, H. T. T. 2014. Rapid detection of equine influenza virus H3N8 subtype by insulated isothermal RT-PCR (iiRT-PCR) assay using the POCKITTM nucleic acid analyzer. J. Virol. Methods. 207:66-72.

*Balasuriya, U. B. R., Zhang, J., Go, Y. Y., and MacLachlan, N. J. 2014. Experiences with infectious cDNA clones of equine arteritis virus: Lessons learned and insights gained (Invited Review). Virology. 462-463:388-403.

ƒMiszczak, F., Tesson, V., Kin, N., Dina, J., Balasuriya, U. B. R., Pronost, S., and Vabret, A. 2014. First detection of equine coronavirus (ECoV) in Europe. J. Clin. Microbiol. 171(1-2):206-9.

Archambault, D., *Balasuriya, U. B. R., Rowland, R. R. R., Yang, H., and Yoo, D. 2014. Animal arteriviruses infections (Editorial). 2014 BioMed Res. Int. (Special Issue of Animal Arterivirus Infections). Vol. 2014, Article ID 303841, http://dx.doi.org/10.1155/2014/303841, 1-2. Epub 2014 Jun 23.

#Go, Y. Y., Li, Y., Chen, Z., Yoo, D., Fang, Y., and *Balasuriya, U. B. R. 2014. Equine arteritis virus does not induce type I interferon α/β production in equine endothelial cells: Identification of nonstructural protein 1 as a main interferon antagonist. 2014. BioMed Res. Int. (Special Issue of Animal Arterivirus Infections). Volume 2014, Article ID 420658, 1-13 pages http://dx.doi.org/10.1155/2014/420658, 1-13.

Go, Y. Y., Balasuriya, U. B. R., and Lee, C. 2014. Zoonotic encephalitides caused by arboviruses: transmission and epidemiology of alphaviruses and flaviviruses. Clin. Exp. Vac. Res. 3:58-77.

Chung, C., Wilson, C., Timoney, P. J., Balasuriya, U. B. R., Adams, E., Adams, D. S., Evermann, J. F., Clavijo, A., Shuck, K. M., Rodgers, S., Lee, S. S., and McGuire, T. C. 2013. Validation of a competitive enzyme-linked immunosorbent assay to detect equine arteritis virus antibody. J. Vet. Diagn. Invest. 25(6): 727-735.

Chambers, T. M., Balasuriya, U. B. R., Reedy, S. E., and Tiwari, A. 2013. Replication of avian influenza viruses in equine tracheal epithelium but not in horses. Influenza and Other Respiratory Viruses. 4: 90-3. 

#Mondal, S. P., Balasuriya, U. B. R., and Yamage, M. 2013. Genetic diversity and phylogenetic analysis of highly pathogenic avian influenza (HPAI) H5N1 viruses circulating in Bangladesh from 2007-2011. Transbound Emerg. Dis. 60:481-491.

*Balasuriya, U. B. R., Go, Y. Y., and MacLachlan, N. J. 2013. Equine arteritis virus (Invited Review). Vet. Microbiol. 167 (1-2): 93-122. 

#Mondal, S. P., Chang, Y., and Balasuriya, U. B. R. 2013. Sequence analysis of infectious bronchitis virus isolates from the 1960s in the United States. Arch. Virol. 158(2):497-503.

#Go, Y. Y., Bailey, E., Timoney, P. J., Shuck, K. M., and *Balasuriya, U. B. R. 2012. Evidence that in vitro susceptibility of CD3+ T lymphocytes to equine arteritis virus infection reflects genetic predisposition of naturally infected stallions to become carriers of the virus. J. Virol. 86(22):12407-10.

Kydd, J. H., Slater, J., Osterrieder, N., Lunn, D. P., Antczak, D. F., Azab, W., Balasuriya, U. B. R., Barnett, C., Brosnahan, M., Cook, C., Damiani, A., Elton, D., Frampton, A., Gilkerson, J., Goehring, L., Horohov, D., Maxwell, L., Minke, J., ,Morley, P., Nauwynck, H., Newton, R., Perkins, G., Pusterla, N., Soboll-Hussey, G., Traub-Dargatz, J., Townsend, H., Van de Walle, G. R., and Wagner, B. 2012. Third International Havemeyer Workshop on Equine Herpesvirus Type 1, Home Ranch, Clarke, Steam Boat Springs, Colorado, USA, 19th-22nd September 2011. Equine. Vet. J. 44(5):513-17.

#Lu, Z., Timoney, P. J., White, J., and *Balasuriya, U. B. R. 2012. Development of One-Step TaqMan® real-time reverse transcription-PCR and conventional reverse transcription PCR assays for the detection of equine rhinitis A and B viruses. BMC Vet. Res. 25;8(1):120-29.

#Zhang, J., Go, Y. Y., Huang, C. M., Meade, B. J., Lu, Z., Snijder, E. J., Timoney, P. J., *Balasuriya,U. B. R. 2012. Development and characterization of an infectious cDNA clone of the modified live virus vaccine strain of equine arteritis virus and its potential as a vaccine vector. Clin. Vaccine Immunol. 19(8):1312-21.

#Lu,, Z., Zhang, J., Huang, C. M., Go, Y. Y., Faaberg, K. S., Rowland, R. R., Timoney, P. J., and *Balasuriya, U. B. R. 2012. Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome do not change the cellular tropism of equine arteritis virus. Virology 432(1):99-109.

#Smith, K. L., Li, Y., Breheny, P., Cook, R. F., Henney, P. J., Sells, S., Pronost, S., Lu, Z., Crossley, B. M., Timoney, P. J., and *Balasuriya, U. B. R. 2012. A new allelic discrimination real-time PCR assay for detection and differentiation of A2254 and G2254 strains of equine herpesvirus-1. J. Clin. Microbiol. 50(6):1981-88.

Ault, A., Zajac, A. M., Kong, W. P., Gorres, J. P., Royals, M., Wei, C. J., Bao, S., Yang, Z., Reedy, S. E., Sturgill, T. L., Page, A. E., Newman, J. D., Adams, A. A., Balasuriya, U. B. R., Horohov, D. W., Chambers, T. M., Nabel, G. J., and Rao, S. S. 2012. Immunogenicity and clinical protection against equine influenza by gene-based DNA vaccination of ponies. Vaccine 30:3965-74. 

#Go, Y. Y., Cook, R. F., Fulgencio, J. Q., Campos, J. R., Henney, P., Timoney, P. J., Horohov, D. W., *Balasuriya, U. B. R. 2012. Assessment of correlation between in vitro CD3+ T cell susceptibility to EAV infection and clinical outcome following experimental infection. Vet. Microbiol. 157:220-25.

ƒMiszczak, F., Legrand, L., Balasuriya, U. B. R., Ferry-Abitbol, B., Zhang, J., Hans, A., Fortier, G., Pronost, S., Vabret, A. 2011. Emergence of novel equine arteritis virus (EAV) variants during persistant infection in the stallion: origin of the 2007 French EAV outbreak was linked to an EAV strain present in the semen of a persistently infected carrier stallion. Virology 423:165-74. 

#Go, Y. Y., Bailey, E., Cook, D. G., Coleman, S. J., MacLeod, J. N., Chen, K. C., Timoney, P. J. and *Balasuriya, U. B. R. 2011. Genome-wide association study among four horse breeds identifies a common haplotype associated with the in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection. J Virol. 85(24):13174-84.

ƒMiszczak, F., Shuck, K. M., Lu, Z., Go, Y. Y., Zhang, J., Sells, S., Vabret, A., Pronost, S., Fortier, G., Timoney, P. J., and *Balasuriya, U. B. R. 2011. Evaluation of two magnetic bead-based viral nucleic acid purification kits and three real-time RT-PCR reagent systems in two TaqMan assays for equine arteritis virus detection. J. Clin. Microbiol. 49(10):3694-96.

Broaddus, C. C., Balasuriya, U. B. R., White, J., Timoney, P. J., Makloski, C., Torrisi, K., and Holyoak, G. R. 2011. Infection of embryos following insemination of donor mares with equine arteritis virus infective semen. Theriogenology 76:47-60.

Firth, A. E., Zevenhoven-Dobbe, J. C., Wills, N. M., #Go, Y. Y., Balasuriya, U. B. R., Atkins, J. F., Snijder, E. J., and Posthuma, C. C. 2011. Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. J. Gen. Virol. 92(5):1097-1106. 

#Go, Y. Y., Snijder, E. J., Timoney, P. J., and *Balasuriya, U. B. R. 2011. Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus. Clin. Vaccine Immunol. 18(2):268-279.

Broaddus, C. C., Balasuriya, U. B. R., White, J., Timoney, P. J., Funk, R. A., and Holyoak, G. R. 2011. Evaluation of the safety of vaccinating mares against equine viral arteritis during mid or late gestation or during the immediate postpartum period. J. Am. Vet. Med Assoc. 238(6):741-750.

Brault, S. A., Bird, B. H., Balasuriya, U. B. R., and MacLachlan, N. J. 2011. Genetic heterogeneity and variation in viral load during equid herpesvirus-2 infection of foals. Vet. Microbiol. 147(3-4):253-261.

#Lu, Z., Dubovi, E. J., Zylich, N., Crawford, P. C., Sells, S., Go, Y. Y., Loynachan, A. T., Timoney, P. J., Chambers, T. M., and *Balasuriya, U. B. R. 2010. Diagnostic application of H3N8 specific equine influenza real-time RT-PCR assays for the detection of canine influenza virus in clinical specimens. J. Vet. Diagn. Invest. 22(6):942-945.

Pronost, S., Cook, R. F., Fortier, G., Timoney, P. J., and *Balasuriya, U. B. R. 2010. Relationship between equine herpesvirus-1 myeloencephalopathy and viral genotypes. Eq. Vet. J. 42(8):672-674.

Pronost, S., Pitel, P. H., Miszczak, F., Legrant, L, Marcillaud-Pitel, C., Hamon, M., Tapprest, J., Balasuriya, U. B. R., Freymuth, F., and Fortier, G. 2010. Description of the first recorded major occurrence of equine viral arteritis in France. Equine Vet. J. 42(8):713-720..

#Zhang, J., Timoney, P. J., Shuck, K. M., Seoul, G., Go, Y. Y., Lu, Z., Powell, D. G., Meade, B. J., and *Balasuriya, U. B. R. 2010. Molecular epidemiology and genetic characterization of equine arteritis virus isolates associated with the 2006-2007 multi-state disease occurrence in the USA. J. Gen. Virol. 91: 2286-2301.

#Go, Y. Y., Zhang, J., Timoney, P. J., Cook, R. F., Horohov, D. W., and *Balasuriya U. B. R. 2010. Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes. J Virol. 84(10): 4898-4911.

#Zhang, J., Stein, D. A., Timoney, P. J., and *Balasuriya, U. B. R. 2010. Curing of HeLa cells persistently infected with equine arteritis virus by a peptide-conjugated morpholino oligomer. Virus Res. 150(1-2):138-142. 

#Smith, K. L., Allen, G. P., Branscum, A. J., Cook, R. F., Vickers, M. L., Timoney, P. J., and *Balasuriya, U. B. R. 2010. Increased prevalence of neuropathogenic strains of EHV-1 in equine abortions. Vet. Micro. 141:5-11.

* Denotes corresponding author
# Denotes publications that were derived from research of students or postdoctoral scholars under my direct supervision
ƒ Denotes publications that were derived from research of visiting scientists

Book Chapters

Balasuriya, U. B. R., and Zhang, J.  2015.  Development and characterization of infectious cDNA clones of equine arteritis virus.  In: Methods in Molecular Biology: Reverse Genetics of RNA viruses. Edited by Daniel R. Perez.  Humana Press, Springer, NY (In preparation).

Balasuriya, U. B. R., and William K. Reisen.  2015.  Flaviviridae (Chapter 30).  In: Fenner’s Veterinary Virology (Fifth edition), Edited by N. James MacLachlan and Edward J. Dubovi.  Academic Press Elsevier, Burlington, MA, USA (Submitted).

Balasuriya, U. B. R., and William K. Reisen.  2015.  Togaviridae (Chapter 29).  In: Fenner’s Veterinary Virology (Fifth edition), Edited by N. James MacLachlan and Edward J. Dubovi.  Academic Press Elsevier, Burlington, MA, USA (Submitted).

Balasuriya, U. B. R.  2015.  Arteriviridae and Roniviridae (Chapter 25).  In: Fenner’s Veterinary Virology (Fifth edition), Edited by N. James MacLachlan and Edward J. Dubovi.  Academic Press Elsevier, Burlington, MA, USA (Submitted).

Chambers, T. M., and Balasuriya, U. B. R.  2015.  Equine influenza virus (Chapter 44).  In: Molecular detection of animal viral pathogens, Edited by Dongyou Liu.  Taylor & Francis CRC Press, Boca Rotan, FL, USA (In press).

Balasuriya, U. B. R.  2015.  Equine arteritis virus (Chapter 31).  In: Molecular detection of animal viral pathogens, Edited by Dongyou Liu.  Taylor & Francis CRC Press, Boca Rotan, FL, USA (In press).

Balasuriya, U. B. R.  2014.  Type A influenza virus detection by RT-PCR from horses.  In: Methods in Molecular Biology, Edited by Erica Spackaman.  Humana Press, Springer, NY.  pp 393-402.

Balasuriya, U. B. R.  2014.  RNA extraction from equine samples.  In: Methods in Molecular Biology, Edited by Erica Spackaman.  Humana Press, Springer, NY.  pp 379-392.

Balasuriya, U. B. R. and MacLachlan, N. J.  2013.  Equine viral arteritis (Chapter 15). In: Infectious Diseases of the Horse (Second edition).  Edited by D. C. Sellon and M. T. Long.  Saunders Elsevier, St. Louis, MO.  pp 169-181.

Balasuriya, U. B. R.  2013.  Arteriviridae and Roniviridae (Chapter 63)In:  Veterinary Microbiology (Third edition), Edited by D. S. McVey, M. M. Chengappa and M. Kennedy.  Blackwell Publishing, Ames, IA. pp 474-490.

Balasuriya, U. B. R.  2013.  Coronaviridae (Chapter 62)In:  Veterinary Microbiology (Third edition), Edited by D. S. McVey, M. M. Chengappa and M. Kennedy.  Blackwell Publishing, Ames, IA. pp 456-473.

Faaberg, K. S., Balasuriya, U. B. R., Brinton, M. A., Gorbalenya, A. E., Leung, F. C.-C., Nauwynck, H., Snijder, E. J., Stadejek, T., Yang, H., and Yoo, D.  2012.  Family Arteriviridae. In: Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses. Edited by A. M. Q. King, M. J. Adams, E. B. Carters, and E. J. Lefkowitz, London: Elsevier Academic Press, pp 796-805.

Balasuriya, U. B. R., and Snijder, E. J.  2007.  Arteriviruses.  In: Animal Viruses: Molecular Biology.  Edited by T. C. Mettenleiter and F. S., Caister, Academic Press, Chapter 3, pp 97-148.

MacLachlan, N. J., and Balasuriya, U.B. R., Murtaugh, M. P., Barthold, S. W., and Lowenstine, L. J.  2007.  Arterivirus pathogenesis and immune response.  In: Nidoviruses. Edited by S. Perlman, American Society for Microbiology Press, Chapter 21, pp 325-337.

Balasuriya, U. B. R., and MacLachlan, N. J.  2007.  Equine viral arteritis. In: Infectious Diseases of the Horse.  Edited by D. Sellon and M. Long, Saunders Elsevier, Chapter 14, pp 153-164.

MacLachlan, N. J., and Balasuriya, U.B. R.  2006.  Equine viral arteritis.  In: Advances in Experimental Biology, volume 581.  Edited by S. Perlman, Kluwer Academic/Plenum Publishers. pp 429-433 (Review).

Balasuriya, U. B. R., and Stott, J. L. 2004.  Coronaviridae and Arteriviridae.  In:  Veterinary Microbiology (Second edition), Edited by D. C. Hirsh et al., Blackwell Publishing, Ames, IApp. 383-397.

Hedges, J. F., Balasuriya, U. B. R., Topol, J. B., Lee, D. W. and MacLachlan, N. J.  2001.  Genetic variation of ORF3 and 4 of equine arteritis virus.  In: Advances in Experimental Biology (The Nidoviruses), Edited by E. Lavi et al.  Kluwer Academic/Plenum Publishers.  pp. 69-72.

Balasuriya, U. B. R., Hedges, J. F., and MacLachlan, N. J.  2001.  Molecular epidemiology and evolution of equine arteritis virus.  In: Advances in Experimental Biology (The Nidoviruses), Edited by E. Lavi et al.  Kluwer Academic/Plenum Publishers.  pp. 19-23.

 

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