Animal Genetic Testing & Research Laboratory
University of Kentucky College of Agriculture, Food & Environment

 

Department of Veterinary Science > Graves, KT > Curriculum Vitae

CURRICULUM VITAE

Kathryn T. Graves, Ph.D.
ktgraves@uky.edu
(859) 218-1193

Assistant Clinical Professor
Department of Veterinary Science
Gluck Equine Research Center
College of Agriculture, Food & Environment
University of Kentucky


Education

1985; Ph.D., Cornell University, Ithaca, NY

1980; BS, magna cum laude, Cook College, Rutgers University, New Brunswick, NJ

Employment

2010 to present - Assistant Clinical Professor, University of Kentucky, Director- Animal Genetic Testing and Research Lab.

2005-2010 - Assistant Research Professor, University of Kentucky, Director-Animal Genetic Testing and Research Lab.

1986-2005 - Assistant Research Professor, University of Kentucky, Supervisor-Red Cell Typing and Genetic Research Sections, Equine Parentage Laboratory.

1981-1983 - Graduate Research Assistant, Cornell University.

Professional Society Membership

International Society for Animal Genetics

Publications

Dietert, RR, MA Qureshi, KA Trembicki. Developmental expression of chicken fetal antigen on peritoneal macrophage: Implications for hematopoietic differentiation. Proc. Soc. Exp. Biol. Med. 172:84, 1983.

Qureshi, MA, KA Trembicki, JV Jackson, PE Borenstein, RR Dietert. Quail fetal antigen (QFA): Identification and comparison with chicken fetal antigen. Develop. Comp. Immunol. 7:325, 1983.

Trembicki, KA, MA Qureshi, RR Dietert. Avian peritoneal exudate cells: A comparison of stimulation protocols. Develop. Comp. Immunol.8:395, 1984.

Trembicki, KA, MA Qureshi, RR Dietert. Differentiation properties of avian tumor cell lines: Analysis using chicken fetal antigen and other markers. Cancer Research 44:2616, 1984.

Trembicki, KA, RR Dietert. Chicken developmental antigens: Analysis of erythroid populations with monoclonal antibodies. J Exp. Zoo.235:127, 1985.

Trembicki, KA, MA Qureshi, RR Dietert. Monoclonal antibodies reactive to chicken peritoneal macrophages. Proc. Soc. Exp. Biol., 183:28, 1986.

Goodloe, RB, RJ Warren, EG Cothran, SP Bratton, KA Trembicki. Genetic variation and its management applications in Eastern United States feral horses. J. Wildlife Manage. 55(3):412, 1991.

Cummings, JF, A deLahunta, HO Mohammed, TJ Divers, B Valentine, BA Summers, BJ Cooper, DF Holmes, KA Trembicki. Equine Motor Neuron Disease: A new neurologic disorder. Equine Practice. 13(9):15, 1991.

Lear , TL, KT Graves, RB Ennis. Identification of equine chromosomes in horse-mouse somatic cell hybrids. Cytogen. and Cell Genetics. 61:58, 1992.

Cummings, JF, A deLahunta, BA Summers, HO Mohammed, TJ Divers, BA Valentine, K Trembicki-Graves. Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study. Acta Neuropath. 85:291, 1993.

Mohammed, HO, JF Cummings, TJ Divers, B Valentine, A deLahunta, B Summers, BRH Farrow, KA Trembicki-Graves. Risk factors associated with Equine Motor Neuron Disease: A possible model forhuman MND. Neurology 43:966, 1993.

Maury, WJ,S Carpenter, KT Graves, B Cheseboro. Cellular and viral specificity of Equine Infectious Anemia Virus Tat transactivation. Virology 200, 632-642, 1994.

Bailey, E.G., KT Graves, EG Cothran, R. Reed, TL Lear, RB Ennis. Synteny mapping horse microsatellite markers using heterohybridoma panel. Animal Genetics 26: 177-180, 1995.

Mellersh, CS, KT Graves, B McLaughlin, RB Ennis, L Pettitt, M Vaudin, KC Barnett.   Mutation In HSF4 Associated With Early But Not Late-Onset Hereditary Cataract In The Boston Terrier. Journal of Heredity 98(5):531-533, 2007.

Graves, KT, PJ Henney and RB Ennis.  Partial Deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in the American Saddlebred Horse. Animal Genetics 40(1):35-41, 2009.

Sequence Submissions

Canis familiaris galactokinase gene (GALK1). Complete codons. GenBank Accession AY267338.KT Graves and RB Ennis. 2003.

Equus caballus laminin alpha3 (LAMA3) gene, intron 25 gi|190684638|gb|EU780072.1|[190684638]  KT Graves and PJ Henney.2008

Equus caballus laminin alpha3 chain (LAMA3) gene, exons 23 through 28 and partial cdsgi|188535622|gb|EU704008.1|[188535622] KT Graves and PJ Henney. 2008.

Equus caballus chromosome 8 laminin alpha3 chain (LAMA3) gene, breakpoint region between intron 23 and intron 28 in JEB-affected Saddlebreds. LOCUS EU812567  5027 bp DNA linear  MAM 19-JUN-2008.  KT Graves and PJ Henney.

TPA_exp: Equus caballus laminin alpha3 chain (LAMA3) gene, exons 23 through 28 and partial cds. LOCUS  BK006617 13459 bp DNA  linear  MAM 22-JAN-2009.  KT Graves and PJ Henney.

Book Chapters

Dietert, RR, MA Qureshi, W Gause, KA Trembicki, J Marsh. Detection of macrophage populations in the thyroids of Obese Strain chickens using monoclonal antibodies. Avian Immunology; ed. WT Weber and DL Ewert. pp. 109-123: Alan R. Liss, Inc., NY, 1987.

Bailey, E, EG Cothran, KA Trembicki. Parentage Testing in Horses. Equine Reproduction; ed. JL Voss and AO McKinnon. pp. 626-630.Lea & Febiger, Malvern, Pa. 1993.

Graves, KT. Genetic Testing in Dogs. The Boston Terrier, by Michael and Beverly Staley. Howell Book Service, New York, NY 1995.

Abstracts

Dietert, RR, KA Trembicki, MA Qureshi. Chicken fetal antigen as a differentiation marker on avian tumor cell lines. Oncodev. Bio. Med.AB2:A91, 1982.

Trembicki, KA, MA Qureshi, RR Dietert. Developmental restriction of chicken fetal antigen on activated peritoneal macrophage. Poult. Sci.61:1557, 1982.

Qureshi, MA, KA Trembicki, RR Dietert. Chicken fetal antigen on normal and tumorigenic hematopoietic cells. Fed. Proc. 42(3):399, 1983.

Trembicki, KA, MA Qureshi, RR Dietert. Stimulation of avian peritoneal exudate cell populations: A comparative study. Poult. Sci. 62(7):1514, 1984.

Trembicki, KA, RR Dietert. Monoclonal antibody to an avian developmental antigen. Fed. Proc. 43(6):1772, 1984.

Dietert, RR, KA Trembicki, DP Hartwell, BF Sanders. Monoclonal antibodies to chicken fetal antigen: Identification of erythroid subpopulations. Tumor Biol. 1984.

Trembicki, KA, MA Qureshi, RR Dietert. Monoclonal antibodies to chicken macrophages: Identification of subpopulations. ISABR20:114, 1986.

Cothran, EG, RB Goodloe, KA Trembicki, R Warren. Genetics of Barrier Island horses. ISABR 21:11, 1988.

Carroll, CS, EG Cothran, KA Trembicki. A BC phenotype in the Q blood group system in horses of feral origin. Animal Genetics 22:10, 1991.

Graves, KT, RB Ennis, TL Lear, N Raney. Isozyme production and enumeration of horse chromosomes in horse-mouse somatic cell hybrids. Animal Genetics 23:F17, 1992.

Bailey, E, KT Graves, EG Cothran. Synteny mapping in the horse. Proceedings of International Conference on Comparative Gene Mapping in Terrestrial and Aquatic Vertebrates, 47, 1994.

Bailey, E.G., KT Graves, E.G. Cothran, R. Reed, TL Lear, and RB Ennis. Gene mapping the horse using microsatellite markers and somatic cell hybrids. Meeting on Genetic Diseases in the Horse, Sept. 1994 Interlaken Switzerland (Poster presentation).

Graves, KT, N Raney, R Ennis, l Coogle, R Reid, E Bailey, L Van de Goor, EG Cothran, G Guerin, L Skow, M Breen, K Bell. Equine gene mapping: Synteny mapping DNA markers. International Society for Animal Genetics, C069, 1996,Tours, France.

Raney, NR, KT Graves, EG Cothran, E Bailey, L Coogle. Synteny Mapping of the horse using a heterohybridoma panel. International Conference on the Status of Plant and Animal Genome Research. P325, San Diego, CA 1998.

Graves, KT, RB Ennis, P. Henney. Y. Long, L.B. Daugherty. Approaches to identifying a marker for juvenile cataracts in Boston Terriers. International Society for Animal Genetics, 1998, Auckland, New Zealand.

Terry, R.R., NE Raney, KT Graves, LT Lieto, PJ Venta, SL Ewart, EG Cothran, EF Bailey, L. Coogle. Synteny mapping of the horse using universal mammalian sequence tagged sites of coding genes and a heterohybridoma panel. International Conference on the Status of Plant and Animal Genome Research. P219. San Diego, CA 1999.

Graves, KT and RB Ennis. Comparison of GALK1 exon sequences in four breeds of dogs affected by juvenile cataracts. E004, pg. 103. International Society for Animal Genetics, 2000, Minneapolis, MN.

Cothran, EG, KT Graves and R.Juras. Linkage disequilibrium analysis of Degenerative Suspensory Ligament Desmitis in the Peruvian Paso. 5th International Equine Gene Mapping Workshop conducted by the Dorothy Russell Havemeyer Foundation at Kruger National Park, South Africa, August 11-14, 2003.

Cothran, EG, KT Graves, R Juras and D Strong. Linkage disequilibrium analysis of degenerative suspensory ligament desmitis in the Peruvian Paso horse. D045, pg 91. International Society For Animal Genetics, 2004, Tokyo, Japan.

Mellersh, CS, KT Graves,  L Pettitt, OP Forman, M Vaudin, KC Barnett.  Different Mutations Within A Single Gene Are Associated With Recessive And Dominant Forms Of Hereditary Cataract In Different Breeds Of Dog. Presented by CS Mellersh at Advances in Canine and Feline Genomics Conference III, Davis, CA, 2006.

Graves, KT, RB Ennis, LB Daugherty, SA Brooks.  A SNP in the horse KIT gene as a new marker for the tobiano spotting pattern. D218, pg 23.  International Society For Animal Genetics, 2006, Porto Seguro, Brazil.

Graves, KT, PJ Henney and RB Ennis.   A 6589 bp deletion in the LAMA3 gene is associated with hereditary junctional epidermolysis bullosa (JEB) in the American Saddlebred Horse.  2229 International Society For Animal Genetics, 2008, Amsterdam, The Netherlands.

McGee RB, Lear TL, Graves KT , Bailey EP. XY Sex Reversal in Mares. P628 Plant & Animal Genomes XVIII Conference, San Diego CA, 2010.

Graves, KT and PJ Henney.  Evaluation of candidate genes for late onset hereditary juvenile cataract in the Boston Terrier.  P5025 International Society for Animal Genetics, 2010 Edinburgh, Scotland.

Other Publications

Graves, KT. Searching for the Juvenile Cataract Gene, American Kennel Club Gazette, pp. 86-88, May 1994.

Graves, KT. Juvenile Cataracts. The Frenchie Forum, Official publication of the French Bulldog Club of America. 11:2, June 2003, pp 56-57.

Graves, KT. Genetic Disease In The Horse. Journal of Equine Veterinary Science, 26:6 p. 255.

Graves, KT, Producing Color, Kentucky Mountain Saddle Horse News, 12:2, p. 22, 2006.

Graves, KT, DNA Testing In Horses, The Friesian, Oct/Nov 2007 pp 25-27.

Graves, KT, Neonatal Isoerythrolysis.  Equine Disease Quarterly 19:1, 2010.

Grant Proposals

Extramural Funding

Principal Investigator. Canine Health Foundation. Genome-Wide Scan To Identify Candidate Genes For Inherited Cataracts In Dogs. Amount requested: $130,246. 2005-2007. Not funded.

Principal Investigator: Canine Health Foundation. Exploration of a single nucleotide polymorphism in the GALK1 gene as a potential marker for juvenile cataracts in the Boston Terrier. Amount requested: $5397.00 Funded.

Principal Investigator: Canine Health Foundation. Galactokinase 1: A Candidate Gene For Juvenile Cataracts In Dogs. 2002-2003. $22,946. $20,946 Funded.

Co-Investigator: The Jockey Club, Development and characterization of horse-specific Single Nucleotide Polymorphisms (SniPs). EG Cothran and KT Graves. 1998. Amount requested $30,500. Funded.

Co-Investigator: Morris Animal Foundation-Synteny Mapping of Coding Genes in New World Camelids, E.G. Cothran and K.T. Graves. 1997-99. $57,000 requested. Approved $28,500.

Principal Investigator: University of Kentucky Research Committee Grant. Linkage Study to Identify a Microsatellite Marker for Juvenile Cataracts in the Boston Terrier.K.T. Graves$4300 requested, $3000 funded. 1997-1998.

Co-Investigator: USDA National research Initiative Competitive Grants Program, Development of a 250 Marker Comparative Syntenic Map for the Horse. E. Bailey (PI) and KT Graves. 1996-1999. $360,465 requested. Not funded.

Grayson Jockey Club Research Foundation. Gene Map of the Horse. E. Bailey (PI), KT Graves, EG Cothran, TL Lear, L Coogle, co-investigators. 1996-1998. $97,332 requested.

Grayson Jockey Club Research Foundation, Gene Map of the Horse. E. Bailey (PI), Kathryn T. Graves, E.G. Cothran, Teri Lear, co-investigators. 1994-1996. $87,412. Funded.

Principal Investigator: Morris Animal Foundation. Identification of a genetic marker for the juvenile cataract gene in dogs using bulk segregant RAPD analysis 1994-1996, $50,000 (approved, not funded).

Private Funding

Co-Principal Investigator: Peruvian Paso Research Foundation. Genetics of DSLD (Degenerative Suspensory Ligament Desmitis). E. Gus Cothran and Kathryn T. Graves. 2003-2005. $200,000.

Co-Investigator: Belgian Horse Society ($30,000) and American Saddlebred Horse Association ($32,000). Investigation of Laminin 5 as a Candidate Gene for Epitheligenesis Imperfecta. E. Gus Cothran and Kathryn T. Graves. 2002-2006. $62,000.

Principal Investigator: Galactokinase as a candidate gene for cataracts in dogs. 1995-2000. Supported with private donations. $5791.00.

Professional Activities

Ad hoc grant reviewer- Canine Health Foundation, 1997,1998, 2002, 2008, 2009.

Ad Hoc reviewer-Journal of Heredity 2005.

Chair- Dog Map Committee. International Society for Animal Genetics. 2004-2008.

Reviewer-Abstracts for International Society of Animal Genetics Conference XXX, 2006.

Meetings

International Society for Animal Genetics XXXII, Edinburgh, Scotland.  Poster presented, Dog Genome Map workshop Co-Chair 2010.

International Society for Animal Genetics XXXI, Amsterdam, The Netherlands.  Poster presented, Dog Genome Map workshop Chair 2008.

International Society for Animal Genetics XXX, Porto Seguro, Brazil.  Poster presented. Dog Genome Map workshop Chair 2006.

International Society for Animal Genetics XXIX, Tokyo, Japan. Poster presented. 2004.

International Society for Animal Genetics, XXVII, Minneapolis, MN. Poster presented. 2000.

International Society for Animal Genetics, XXVI, Auckland, New Zealand. Poster presented. 1998.

International Society for Animal Genetics, XXV, Tours, France, 1996. Poster presented.

First International Workshop on Gene Mapping in the Horse, Lexington, KY. 1995.

Molecular Genetics and Canine Genetic Health Conference, Florham Park, N.J., 1994.

International Society for Animal Genetics, XXIII, Interlaken, Switzerland, 1992. Poster presented.

International Society for Animal Genetics, XXII, East Lansing, MI 1990. Poster presented.

International Society for Animal Genetics, XXI, Torino, Italy, 1988. Poster presented.

Universityof Pittsburgh Human Genetics Conference, Pymatuning, PA, 1986.

International Society for Animal Blood Group Research(ISABR) XX, Helsinki, Finland, 1986. Poster presented.

International Society of Oncodevelopmental Biology and Medicine, XII Annual meeting, Houston, TX, 1984. Poster presented.

American Association of Immunologists, FASEB, ST. Louis, MO, 1984. Poster presented.

Poultry Science Association, College Park, MD, 1983. Paper presented.

NE-60 Regional Meeting-Genetic Basis of Resistance to Avian Disease. Ithaca, NY, 1982.

Poultry Science Association, Davis, CA, 1982. Paper presented.

Inter-University Collaboration

Investigation of anti-red cell antibody involvement in stallion infertility. University of Pennsylvania, New Bolton Center, Kennett Square, PA. 1991.

Examination of potential genetic markers for Equine Motor Neuron Disease. John Cummings, PI. New York State College of Veterinary Medicine, Cornell University, Ithaca NY. 1991-1992.

Permissiveness of horse-mouse somatic cell hybrids for Tat transactivation by Equine Infectious Anemia Virus. Wendy Maury, PI. NIH, Rocky Mountain Labs, Hamilton, MT, 1993.

Permissiveness of horse-mouse somatic cell hybrids for infection and replication of Equine Infectious Anemia Virus. Susan Payne, PI. Case Western Reserve University, Cleveland, OH, 1993.

Committee Activity

Graduate Faculty- Associate member, 1988 to present.

Member- Search committee for Warren Wright Sr.-Lucille Markey Chair in Immunology, 1988 to 1990.

Member-Department of Veterinary Science Animal Resources Committee, 1988 to 1995.

Member-Department of Veterinary Science Appointments and Promotions Committee, 1992 to 1999.

Member-Albert and Lorraine Clay Fellowship Award Committee, 1995 to present.

Chair-Department of Veterinary Science Animal Pathology Building Safety Committee, 1996 to 2009.

BEAC Floor Leader-Department of Veterinary Science 2009 to present.

Member- Department of Veterinary Science Advisory and Strategic Planning Committee 2008 to present.

Member- Department of Veterinary Science Communications Committee 2007 to present.

Student Advising

Graduate

Nancy Raney, MS. Graduate, Major Advisor, 1994-1999.

Teri Lear, Ph.D. candidate, Advisory Committee member, 1993-1997.

Jennifer Leigh Myka, Ph.D.candidate, Advisory Committee member, 1994.

Diane Strong, MS candidate, Advisory Committee Member, 2004-present.

Undergraduate

Brian York, Biotechnology Program. Project Advisor “Identifying a DNA marker for cataracts in a family of horses”. 1997-1999.

Nancy Raney, Biotechnology Program. Project and academic advisor. 1990-1994. Recipient of the 1994 Oswald Research and Creativity program award in Biological Sciences for the paper "Use of Horse-Mouse Somatic Cell Hybrids for Gene Mapping in the Horse"

Pre-veterinary advisor, 1994-2009.

Public Service

Presentation on "Horse Blood Typing at the University of Kentucky", to the Steward Accreditation class of the University of Louisville. 1990.

Officiating as judge at the State 4-H Horse Bowl Contest. University of Kentucky, Lexington, 1990.

1990 ITEC Conference-Presentation on Horse Blood Typing at the Kentucky Equine Research Foundation booth.

Officiating as judge at the State 4-H Horse Bowl contest, Louisville, 1992.

Presentation "Juvenile Cataracts-Potential for Genetic Testing" at the National Specialty Show of the Boston Terrier Club of America, 1993. Invited Speaker.

Elected Representative of the Boston Terrier Club of America at the AKC Parent Club Genetic Conference, Florham Park, NJ, 1995.

Officiated as a judge for the 4-H State Horse Demonstration Competition. Lexington, KY 1997.

Invited Speaker. Lexington Kennel Club.“Canine Genetics- Basic Tools for Dog Breeders”. 1997.

Invited Speaker. Lexington Kennel Club. "The Dog Gene Map: Where is it Going?" 1999.

Officiating as judge at the State 4-H Horse Bowl contest, Lexington, 2004.

Presentation: Genetic Testing at the University of Kentucky Equine Parentage Lab.  Presented to the Akhal-Teke Association of America, Lexington KY 2006.

Presentation: Genetic Testing at the University of Kentucky Equine Parentage Lab. Presented at the Horsemen Helping Horseman Education Event, Harrison County 4-H, Cynthiana KY 2007.

Presentation Genetic Testing at the University of Kentucky Equine Parentage Lab.  Presented to the Gotland Pony Society of North America, Lexington KY 2007.

Presentation “The Quest for the EI Mutation: A Success Story” to the American Saddlebred Horse Association Board of Directors, Lexington KY 2007.

Presentation “Genetic Testing In Horses” at the Kentucky Breeders Short Course, Lexington KY 2010.

Presentation “Genetic Testing in Dogs:How to Use It, Not Misuse It” at the United States of America Coton de Tulear Club National Specialty Show, 2010.

Outside Activities

Association Memberships

American Quarter Horse Association-Life Member

American Paint Horse Association

Pinto Horse Association of America

Kentucky Quarter Horse Association

Kentucky Paint Horse Breeders Association- Secretary/Treasurer

Kentucky Paint Horse Club

Pinto Organization of Kentucky

Boston Terrier Club of America

Boston Terrier Club of Greater Cincinnati

Boston Terrier Club of Louisville

Lexington Kennel Club