University of Kentucky College of Agriculture, Food & Environment

 

Gluck Center > Directory > Gluck Faculty >Horohov, DW > Curriculum Vitae

CURRICULUM VITAE

David W. Horohov, Ph.D.
David.Horohov@uky.edu
(859) 218-1098

Interim Chairman, Department of Veterinary Science
Interim Director, M.H. Gluck Equine Research Center
Jes E. and Clementine M. Schlaikjer Endowed Chair
M.H. Gluck Equine Research Center
College of Agriculture, Food & Environment
University of Kentucky

Birthdate

September 2, 1956

Education

Penn State University, University Park, PA; B.S. 1978; Entomology

Purdue University, W. Lafayette, IN; M.S. 1981; Insect Pathology

University of Tennessee, Knoxville, TN; Ph.D. 1985; Immunology

Food and Drug Administration, Bethesda, MD; Post-doc 1988; Cytokine Biology

Research and/or Professional Experience

August 2003 - Present; William Robert Mills Chair, Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY

July 1995 - July 2003; Professor of Veterinary Immunology, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA

July 1999 - December 1999; Visiting Scientist, Sabbatical Leave, Animal Health Trust, Newmarket, UK

December 1997; Visiting Professor, Department of Animal Sciences, Cook College, Rutgers University, New Brunswick, NJ.

July 1991 - June 1995;    Associate Professor of Veterinary Immunology, Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA

September 1990 - July 2003; Director, School of Veterinary Medicine's Flow Cytometry Facility, Louisiana State University, Baton Rouge, LA

June 1988 - June 1991; Assistant Professor of Veterinary Immunology, Department of Veterinary Microbiology, and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA

July 1985 - June 1988; Staff Fellow.  Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD

Recent Publications

Tompkins D, Hudgens E, Horohov D, Baldwin CL. 2010. Expressed gene sequences of the equine cytokines interleukin-17 and interleukin-23. Veterinary Immunology and Immunopathology 133: 309-13

Sturgill TL, Horohov DW. 2010. vaccination response of young foals to keyhole limpet hemocyanin: Evidence of effective priming in the presence of maternal antibodies. Journal of Equine Veterinary Science 30: 359-64

Saulez MN, Godfroid J, Bosman A, Stiltner JL, Breathnach CC, Horohov DW. 2010. Cytokine mRNA expressions after racing at a high altitude and at sea level in horses with exercise-induced pulmonary hemorrhage. American Journal of Veterinary Research 71: 447-53

McDowell KJ, Webb BA, Williams NM, Donahue JM, Newman KE, Lindemann MD, Horohov DW. 2010. Invited Review: The role of caterpillars in mare reproductive loss syndrome: A model for environmental causes of abortion. Journal of Animal Science 88: 1379-87

Horohov DW, Adams AA, Chambers TM. 2010. Immunosenescence of the equine immune system. Journal of Comparative Pathology 141: S78-S84

Go YY, Zhang JQ, Timoney PJ, Cook RF, Horohov DW, Balasuriya UBR. 2010. Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3(+) T Lymphocytes and CD14(+) Monocytes. Journal of Virology 84: 4898-911

Dawson TRMY, Horohov DW, Meijer WG, Muscatello G. 2010. Current understanding of the equine immune response to Rhodococcus equi. An immunological review of R. equi pneumonia. Veterinary Immunology and Immunopathology 135: 1-11

Yeargan MR, Lyons ET, Kania SA, Patton S, Breathnach CC, Horohov DW, Howe DK. 2009. Incidental isolation of Setaria equina microfilariae in preparations of equine peripheral blood mononuclear cells. Veterinary Parasitology 161: 142-5

Shakya KP, Miller JE, Horohov DW. 2009. A Th2 type of immune response is associated with increased resistance to Haemonchus contortus in naturally infected Gulf Coast Native lambs. Veterinary Parasitology 163: 57-66

Merant C, Breathnach CC, Kohler K, Rashid C, Van Meter P, Horohov DW. 2009. Young foal and adult horse monocyte-derived dendritic cells differ by their degree of phenotypic maturity. Veterinary Immunology and Immunopathology 131: 1-8

Mealey RH, Leib SR, Littke MH, Wagner B, Horohov DW, McGuire TC. 2009. Viral load and clinical disease enhancement associated with a lentivirus cytotoxic T lymphocyte vaccine regimen. Vaccine 27: 2453-68

Lunn DP, Davis-Poynter N, Flaminio MJBF, Horohov DW, Osterrieder K, Pusterla N, Townsend HGG. 2009. Equine Herpesvirus-1 Consensus Statement. Journal of Veterinary Internal Medicine 23: 450-61

Chambers TM, Quinlivan M, Sturgill T, Cullinane A, Horohov DW, Zamarin D, Arkins S, Garcia-Sastre A, Palese P. 2009. Influenza A viruses with truncated NS1 as modified live virus vaccines: Pilot studies of safety and efficacy in horses. Equine Veterinary Journal 41: 87-92

Adams AA, Katepalli MP, Kohler K, Reedy SE, Stilz JP, Vick MM, Fitzgerald BP, Lawrence LM, Horohov DW. 2009. Effect of body condition, body weight and adiposity on inflammatory cytokine responses in old horses. Veterinary Immunology and Immunopathology 127: 286-94

Wagner B, Hillegas JM, Brinker DR, Horohov DW, Antczak DF. 2008. Characterization of monoclonal antibodies to equine interleukin-10 and detection of T regulatory 1 cells in horses. Veterinary Immunology and Immunopathology 122: 57-64

Vick MM, Murphy BA, Sessions DR, Reedy SE, Kennedy EL, Horohov DW, Cook RF, Fitzgerald BR. 2008. Effects of systemic inflammation on insulin sensitivity in horses and inflammatory cytokine expression in adipose tissue. American Journal of Veterinary Research 69: 130-9

Marti E, Gerber V, Wilson AD, Lavoie JP, Horohov D, Crameri R, Lunn DP, Antcsak D, Bjornsdottir S, Bjornsdottir TS, Cunningham F, Derer M, Frey R, Hamza B, Horin P, Hermann M, Kolm-Stark G, Olafsdottir G, Ramery E, Russell C, Schaffartzik A, Svansson V, Torsteinsdottir S, Wagner B. 2008. Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Holar, Iceland, June 2007. Veterinary Immunology and Immunopathology 126: 351-61

LeBlanc CJ, Horohov DW, Bauer JE, Hosgood G, Mauldin GE. 2008. Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. American Journal of Veterinary Research 69: 486-93

Katepalli MP, Adams AA, Lear TL, Horohov DW. 2008. The effect of age and telomere length on immune function in the horse. Developmental and Comparative Immunology 32: 1409-15

Horohov DW, Breathnach CC, Sturgill TL, Rashid C, Stiltner JL, Strong D, Nieman N, Holland RE. 2008. In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis. Equine Veterinary Journal 40: 468-72

Adams AA, Breathnach CC, Katepalli MP, Kohler K, Horohov DW. 2008. Advanced age in horses affects divisional history of T cells and inflammatory cytokine production. Mechanisms of Ageing and Development 129: 656-64

Vick MM, Adams AA, Murphy BA, Sessions DR, Horohov DW, Cook RF, Shelton BJ, Fitzgerald BP. 2007. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. Journal of Animal Science 85: 1144-55

Saulez MN, Godfroid J, Bosman A, Hinchcliff KW, Stiltner JL, Breathnach CC, Horohov DW. 2007. Effect of altitude on venous proinflammatory cytokine production in thoroughbred racehorses with exercise-induced pulmonary hemorrhage. Journal of Veterinary Internal Medicine 21: 668-9

Quinlivan M, Nelly M, Prendergast M, Breathnach C, Horohov D, Arkins S, Chiang YW, Chu HJ, Ng T, Cullinane A. 2007. Pro-inflammatory and antiviral cytokine expression in vaccinated and unvaccinated horses exposed to equine influenza virus. Vaccine 25: 7056-64

Penn AL, Rouse RL, Horohov DW, Kearney MT, Paulsen DB, Lomax L. 2007. In utero exposure to environmental tobacco smoke potentiates adult responses to allergen in BALB/c mice. Environ Health Perspect 115: 548-55

LeBlanc CJ, Dietrich MA, Horohov DW, Bauer JE, Hosgood G, Mauldin GE. 2007. Effects of dietary fish oil and vitamin E supplementation on canine lymphocyte proliferation evaluated using a flow cytometric technique. Veterinary Immunology and Immunopathology 119: 180-8

Fitzgerald BP, Horohov DW, Lang D, Christiansen DL, Hopper RM, Ryan PL. 2007. Perturbations in macrophage inflammatory cytokine mRNA expression in mares exposed to endophyte-infected tall fescue pastures. Theriogenology 68: 496-7

Breathnach, C. C., T. Sturgill-Wright, J. L. Stiltner, A. A. Adams, D. P. Lunn, and D. W. Horohov. (2006). Foals are interferon gamma-deficient at birth. Veterinary immunology and immunopathology 112:199-209. PubMed. PDF.

Pena, M. T., J. E. Miller, and D. W. Horohov. (2006). Effect of CD4+ T lymphocyte depletion on resistance of Gulf Coast Native lambs to Haemonchus contortus infection. Veterinary parasitology 138:240-246. PubMed. PDF.

Slater, J. D., D. P. Lunn, D. W. Horohov, D. F. Antczak, L. Babiuk, C. Breathnach, Y. W. Chang, N. Davis-Poynter, N. Edington, S. Ellis, C. Foote, L. Goehring, C. W. Kohn, J. Kydd, T. Matsumura, J. Minke, P. Morley, J. Mumford, T. Neubauer, D. O'Callaghan, K. Osterrieder, S. Reed, K. Smith, H. Townsend, K. van der Meulen, M. Whalley, and W. D. Wilson. (2006). Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004. Veterinary immunology and immunopathology 111:3-13. PubMed. PDF.

Miller, J. E., and D. W. Horohov. (2006). Immunological aspects of nematode parasite control in sheep. Journal of animal science 84 Suppl:E124-132. PubMed. PDF.

Horohov, D.W., Beadle, R.E., Mouch, S. & Pourciau, S.S. (2005). Temporal regulation of cytokine mRNA expression in equine recurrent airway obstruction. Vet Immunol Immunopathol 108, 237-45. PubMed. PDF.

Kleiber, C., McGorum, B.C., Horohov, D.W., Pirie, R.S., Zurbriggen, A. & Straub, R. (2005) Cytokine profiles of peripheral blood and airway CD4 and CD8 T lymphocytes in horses with recurrent airway obstruction. Vet Immunol Immunopathol 104, 91-97. PubMed. PDF.

Bowles, K., D. Horohov, D. Paulsen, C. Leblanc, M. Littlefield-Chabaud, T. Ahlert, K. Ahlert, S. Pourciau, & Penn, A. (2005). Exposure of adult mice to environmental tobacco smoke fails to enhance the airway response to inhaled ovalbumin. Inhal Toxicol 17(1), 43-51. PubMed. PDF.

Jackson, K. A., Stott, J. L., Horohov, D. W. & Watson, J. L. (2004). IL-4 induced CD23 (Fc(?)RII) up-regulation in equine peripheral blood mononuclear cells and pulmonary alveolar macrophages. Vet Immunol Immunopathol 101:243-50. PubMed. PDF.

Tetens, J., R. M. Moore, G. L. Hosgood, S. C. Eades, M. L. Keowen, and D. W. Horohov. (2004). Effects of infusion of adenosine triphosphate-magnesium chloride on cardiopulmonary and clinicopathologic variables, cytokine activity, and endothelin concentration in horses administered a low dose of endotoxin. American journal of veterinary research 65:225-237. PubMed. *

Hubert, J.D., Seahorn, T.L., Klei, T.R., Hosgood, G., Horohov, D.W., & Moore, R.M.(2004). Clinical signs and hematologic, cytokine, and plasma nitric oxide alterations in response to Strongylus vulgaris infection in helminth-naïve ponies. Can J Vet Res 68 (3) 193-200. PubMed. PDF.

Pena, M. T., Miller, J. E., & Horohov, D. W. (2004). Effect of dexamethasone treatment on the immune response of Gulf Coast Native lambs to Haemonchus contortus infection. Vet Parasitol 119: 223-35. PubMed. PDF.

Book Chapters

Lunn, D.P. and D.W. Horohov. (2010). The immune system. In "Equine Internal Medicine", S. Reed,  W. Bayly, and D.C. Sellon; eds., Saunders Elsevier, St. Louis, p.1-56.

Horohov, D.W. (2008)  Immunological response to exercise and training. In “Equine Sports Medicine and Training”, K.W. Hinchcliff, K.W., Geor, R.J., and A.J. Kaneps, eds., Saunders Elsiever, Edinburgh, p. 410 -422.

Horohov, D.W. (2004)  Immunological response to exercise and training. In “Equine Sports Medicine and Training”, K.W. Hinchcliff, K.W., Kaneps, A.J., and Geor, R.J. eds., Saunders, Edinburgh, p. 1000-1010.

Fermaglich D.H. and D.W. Horohov.  (2002) The effect of aging on immune responses.  In “The Veterinary  Clinics of  North America Equine Practice: Geriatric Medicine”, J.M. MacLeay, editor, W. B. Saunders Company, Philadelphia.

Horohov D.W. (2000) Equine T-cell cytokines. Protection and pathology. In: “The Veterinary  Clinics of  North America Equine Practice: Equine Immunology”. D.P. Lunn and D.W. Horohov, eds. W. B. Saunders Company, Philadelphia.

Horohov, D.W.,  Swiderski, C.E., Robinson, J.A. and T.R. Klei.  1998.  Cytokine production in various equine disease settings.  In: "Cytokines in Veterinary Medicine", M.C. Horzinek and V.E.C.J. Schilns, eds., CAB International, UK. 

Lunn DP, Hannant D, and D.W. Horohov.  1998.   Immunology of horses and donkeys.  In: “Handbook of Vertebrate Immunology”, P.P. Pastoret,  H. Bazin,  P. Griebel, and H. Govaerts, eds.,  Academic Press, London.

Horohov, D.W. 1997. Contemporary Immunology. In: "Equine Internal Medicine", S. Reed and W. Bayly, eds., W. B. Saunders & Co, Philadelphia, p.1-21.

 

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