University of Kentucky College of Agriculture, Food & Environment

 

Gluck Center > Directory > Gluck Faculty >Howe, DK > Curriculum Vitae

CURRICULUM VITAE

Daniel K. Howe, Ph.D.
dkhowe2@uky.edu
(859) 218-1113

Professor
Department of Veterinary Science
M.H. Gluck Equine Research Center
College of Agriculture, Food & Environment
University of Kentucky

Education

Purdue University (W. Lafayette, IN); Ph.D.: Molecular Parasitology, December 1992

University of Illinois (Urbana, IL); 1990-1991

Western Illinois University (Macomb, IL); M.S.: Biology/Parasitology, July 1990

Western Illinois University (Macomb, IL); B.S.: Biology, May 1988

Appointments and Professional Experience

07/12-Present; Professor, Department of Veterinary Science, M.H. Gluck Equine Research Center, University of Kentucky, Lexington, KY.

08/09-Present; Director of Graduate Studies, Department of Veterinary Science, University of Kentucky, Lexington, KY.

07/05-06/12; Associate Professor, Department of Veterinary Science, M.H. Gluck Equine Research Center, University of Kentucky, Lexington, KY.

07/99-06/05; Assistant Professor, Department of Veterinary Science, M.H. Gluck Equine Research Center, University of Kentucky, Lexington, KY.

01/93-06/99; Postdoctoral Research Associate, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.

Honors/Awards/Fellowships

Amerman Family Equine Research Endowment, 2004-present.

University of Kentucky Faculty Futures Award, 2004.

NIAID Postdoctoral Fellowship, Department of Internal Medicine, Washington University School of Medicine, 1993-1996.

George A. LaRue Award, Outstanding Meeting Presentation and Accomplishments in Parasitology, Annual Midwestern Conference of Parasitologists, Eau Claire, WI, 1992.

Pittsburgh Supercomputing Center Travel Award, Nucleic Acid and Protein Sequence Analysis Workshop, 1992.

Intellectual Property

“Nucleic acids encoding Sarcocystis neurona antigens and uses thereof.”  U.S. patents 7,056,733 7,256,282 and 7,524,946.  Daniel K. Howe, inventor.  Issued 06/06/2006, 08/14/2007, and 04/28/2009.  Technology has been licensed for commercial use (diagnostics) by Equine Diagnostic Solutions, LLC, Lexington, KY.

“Immunological detection of neosporosis using a recombinant antigen.” U.S. patent application #09/767,037.  L.D. Sibley and D.K. Howe, co-inventors.  Filed 06/27/2001. 

Professional Service

Co-Editor-in-Chief, Veterinary Parasitology, 2010-Present.

Editorial Board, Infection and Immunity, 2012-present; Veterinary Parasitology, 2006-2010; Journal of Eukaryotic Microbiology, 2001-2003.

Nominations Committee, Annual Midwestern Conference of Parasitologists, Notre Dame, IN, 2011.

Presiding Officer, Annual Midwestern Conference of Parasitologists, Delaware, OH, 2009.

Stoll-Stunkard Memorial and Eminent Parasitologist Lectureships Committee, American Society of Parasitologists.  2004-2008 (Committee Chair, 2007-2008).

Meeting Site Committee, Annual Midwestern Conference of Parasitologists, Champaign-Urbana, IL, 2008.

Instruction and Training

Undergraduate

Chair, Agricultural Biotechnology Coordinating Committee, 2009-Present

Instructor, ABT 301, Writing and Presentation in the Life Sciences.

Research project advisor for students in Agricultural Biotechnology, Asbury College, Paul Dunbar High School MSTC program.

Graduate

Director of Graduate Studies, University of Kentucky Department of Veterinary Science, 2009-present. 

Graduate Student Committees:  25, 5 as major advisor.

Host for 10 visiting scientists.

Selected Publications

Gautam, A.*, J.P. Dubey, W.J. Saville, and D.K. Howe.  2011.  The SnSAG merozoite surface antigens of Sarcocystis neurona are expressed differentially during the bradyzoite and sporozoite life cycle stages.  Veterinary Parasitology 183:37-42.

Yeargan, M.R.*, and D.K. Howe.  2011.  Improved detection of equine antibodies against Sarcocystis neurona using polyvalent ELISAs based on the parasite SnSAG surface antigens.  Veterinary Parasitology 176:16-22.

Furr, M., Howe, D., Reed, S., and Yeargan, M*.  2011.  Antibody coefficients for the diagnosis of Equine Protozoal Myeloencephalitis.  Journal of Veterinary Internal Medicine 25:138-142.

Gaji, R.Y.*, and D.K. Howe.  2009.  The heptanucleotide motif GAGACGC is a key component of a cis-acting element that is critical for SnSAG1 expression in Sarcocystis neurona.  Molecular and Biochemical Parasitology 166:85-88.

Crowdus, C.A.*, A.E. Marsh, W.J. Saville, D.S. Lindsay; J.P. Dubey, D.E. Granstrom, and D.K. Howe.  2008.  SnSAG5 is an alternative surface antigen of Sarcocystis neurona strains that is mutually exclusive to SnSAG1.  Veterinary Parasitology 158:36-43.

Howe, D.K., R.Y. Gaji*, A.E. Marsh, B.A. Patil*, W.J. Saville, D.S. Lindsay, J.P. Dubey, and D.E. Granstrom.  2008.  Strains of Sarcocystis neurona exhibit differences in their surface antigens, including the absence of the major surface antigen SnSAG1.  International Journal for Parasitology 38:623-631.

Herman, R.K.*, R. Molestina, A. Sinai, and D.K. Howe.  2007.  The apicomplexan pathogen Neospora caninum inhibits host cell apoptosis in the absence of discernible NF-B activation.  Infection and Immunity 75(9):4255-4262.  (Article highlighted in issue’s Spotlight section)

Gaji, R.Y.*, D. Zhang*, C. Breathnach, S. Vaishnava, B. Striepen, and D.K. Howe.  2006.  Molecular genetic transfection of the coccidian parasite Sarcocystis neurona.  Molecular and Biochemical Parasitology 150:1-9.

Zhang, D.*, R.Y. Gaji*, and D.K. Howe.  2006.  Identification of a dithiol-dependent nucleoside triphosphate hydrolase in Sarcocystis neurona.  International Journal for Parasitology 36:1197-1204.  (Featured on Journal cover)

Hoane, J.S.*, J.K. Morrow, W.J. Saville, J.P. Dubey, D.E. Granstrom, and D.K. Howe.  2005.  Enzyme-linked immunosorbent assays for the detection of equine antibodies specific to Sarcocystis neurona surface antigens.  Clinical and Diagnostic Laboratory Immunology 12(9):1050-1056.

Vaishnava, S., D.P. Morrison, R.Y. Gaji*, J.M. Murray, R. Entzeroth, D.K. Howe, and B. Striepen.  2005.  Plastid segregation and cell division in the apicomplexan parasite Sarcocystis neurona.  Journal of Cell Science 118:3397-3407.

Hoane, J.S.*, M.R. Yeargan*, S. Stamper*, W.J. Saville, J.K. Morrow, D.S. Lindsay, and D.K. Howe.  2005.  Recombinant NhSAG1 ELISA: a sensitive and specific assay for detecting antibodies against Neospora hughesi in equine serum.  Journal of Parasitology 91(2):446-452.

Howe, D.K., R. Gaji*, M. Mroz-Barrett*, M-J. Gubbels, B. Striepen, and S. Stamper*.  2005.  Sarcocystis neurona merozoites express a family of immunogenic surface antigens that are orthologues of the Toxoplasma gondii surface antigens (SAGs) and SAG-related sequences.  Infection and Immunity 73(2):1023-1033.

Hoane, J.S.*, V.B. Carruthers, B. Striepen, R. Entzeroth, and D.K. Howe.  2003.  Analysis of the Sarcocystis neurona microneme protein SnMIC10: protein characteristics and expression during intracellular development.  International Journal for Parasitology 33:671-679.

Li, L., B. Brunck, J. Kissinger, D. Pape, K. Tang, R. Cole, J. Martin, T. Wylie, M. Dante, S.J. Fogarty, D.K. Howe, P. Liberator, C. Diaz, J. Anderson, M. White, M.E. Jerome, E.A. Johnson, J.A. Radke, C.J. Stoeckert, Jr., R.H. Waterston, S.W. Clifton, D.S. Roos, and L.D. Sibley.  2003.  Gene discovery in the Apicomplexa as revealed by EST sequencing and assembly of a comparative gene database.  Genome Research 13:443-454.

Su, C., D.K. Howe, J.P. Dubey, J. Ajioka, and L.D. Sibley.  2002.  Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii.  Proceedings of the National Academy of Sciences 99:10753-10758. 

 

Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099

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