University of Kentucky College of Agriculture, Food & Environment

 

Gluck Center > Directory > Gluck Faculty >Lear, T > Research Interests

RESEARCH INTERESTS

Clinical Cytogenetics for Equines

Teri Lear, PhD
equigene@uky.edu
(859) 218-1108

In keeping with the service and outreach mission of the University, my lab offers clinical cytogenetics services to equine veterinarians.  Between 1.5% and 3% of the general horse population carries a chromosome abnormality including abnormalities of sex chromosomes, trisomy and chromosome translocations.  Chromosome abnormalities can profoundly affect fertility and survival.  Cytogenetic techniques used in my lab can identify chromosome abnormalities causing infertility, ambiguous sex, and congenital abnormalities. 

This service is on a fee for service basis.  The lab offers basic chromosome analysis to identify chromosome number, GTG-banding to identify each chromosome and structural chromosome rearrangements, PCR for the presence of a Y chromosome, and fluorescent in situ  hybridization (FISH) with chromosome specific markers useful to confirm chromosome translocation in mares exhibiting repeated early embryonic loss (REEL) or to identify specific chromosomes.  We are now experimenting with the use of single nucleotide polymorphism testing (SNPs) to identify chromosome number abnormalities and genomic deletions/duplication in cases of infertile mares with normal karyotypes. 

We have identified chromosome abnormalities affecting mare fertility, causing severe congenital abnormalities in foals, and causing sexual ambiguity (Lear et al. 1999; Lear and Layton 2002; Lear et al. 2008; Lear and Bailey 2008, Villagomez et al, in press).   

For more information on this service >>>

Karyotype of a mare

 

 

Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099

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