University of Kentucky College of Agriculture

David F. Hildebrand



Directions to University of Kentucky, Lexington, KYUniversity of Kentucky, PSS
Campus LocationPlant Science Building
1405 Veterans Drive (Office:403)
Lexington, KY 40546-0312
Phone(859) 218-0760
Fax(859) 257-7874


Plant Biochemistry & Genetics

B.S. in Agronomy, University of Maryland (1977)

B.S. in Chemistry, University of Maryland (1977)

M.S. in Plant Breeding and Genetics, University of Illinois (1980)

Ph.D. in Plant Breeding and Genetics, University of Illinois (1982)

My research program emphasizes the general area of plant biochemistry and genetics and the application of biotechnology to crop improvement with particular emphasis on food, lipid and oil quality, new uses of agricultural commodities and plant pest defense. This research involves the investigation of metabolic pathways and the identification, isolation, cloning and manipulation by plant genetic engineering of agriculturally important genes. A major research thrust is the understanding and manipulation of fatty acid metabolism and triglyceride synthesis. We are changing triglycerides of oilseeds, with emphasis on soybeans, for improved edible and industrial quality.

Junior Fellowship in biomedical research with US-National Institutes of Health (NIH), 1973-1977.

Research Assistant in Plant Physiology, University of Maryland, 1977.

Graduate Research Assistantships, University of Illinois, 1977-1981.

Graduate Fellowships, University of Illinois, 1979, 1980.

Japanese Society for the Promotion of Science Fellowship for work at Kyoto University Research Institute for Food Science, February 1982-August, 1982.




This person page last updated on 2011-07-19


    Pls609 - Plant Biochemistry; Credits - 3
    The course will consider the chemical constituents of plants (with emphasis on biologically or nutritionally significant compounds unique to plants), their biosynthesis, contribution to key metabolic and defense processes and the regulation of their synthesis. Included will be discussions of photosynthesis, carbohydrates, lipids, isoprenoids and phenylpropanoids, nitrogen fixation, nitrogen and sulfur reduction and assimilation, alkaloids and additional secondary compounds, frontiers in plant biochemistry. Prereq: BCH 607 or equivalent or consent of instructor. (Same as BCH/PPA 609.) .
    Instructors: David F. Hildebrand Ling Yuan

Research/Teaching Publications

    Books and Book Chapters

    Hildebrand, D. 2011. Lipid Biosynthesis. Chapter 2, pp. 25-62. IN: H. Ashihara, A. Crozier, and A. Komamine, eds. Plant Metabolism and Biotechnology. John Wiley & Sons, Ltd., West Sussex, UK.
    Hildebrand, D. 2010. Production of Unusual Fatty Acids in Plants. AOCS Lipid Library. Published online:
    Hildebrand, D., R. Li, K. Yu, and T. Hatanaka. 2009. Accumulation of epoxy fatty acids in plant oils. Chapter 3. IN: C.T. Hou and J.F. Shaw, ed. Biocatalysis and Agricultural Biotechnology. CRC Press, Boca Raton, Fla.
    Mendu, V., and D.F. Hildebrand. 2007. Plant hydroperoxide lyases and related enzymes. Chapter 24, pp. 399-417. IN: Ching Hou, ed. Biocatalysis and Biotechnology for Functional Foods and Industrial Products. Taylor and Francis, New York.

    Refereed Journal Articles

    Abdel-Reheem, M., and D. Hildebrand. 2013. Activity of Brassica napus and Perilla frutescens microsomal omega-3 desaturases expressed in yeast (Saccharomyces cerevisiae). Turkish Journal of Biology 37(5):591–605. Published online: doi:10.3906/biy-1301-32.
    Li, R.Z., T. Hatanaka, K.S. Yu, Y.M. Wu, H. Fukushige, and D. Hildebrand. 2013. Soybean oil biosynthesis: Role of diacylglycerol acyltransferases. Functional and Integrative Genomics 13(1):99–113. Published online: doi:10.1007/s10142-012-0306-z.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Jamboonsri, W., T. D. Phillips, R. L. Geneve, J. P. Cahill, and D. Hildebrand. 2012. Extending the range of an ancient crop, Salvia hispanica L.-a new ω3 source. Genetic Resources and Crop Evolution 59(2): 171-178. (Watchareewan Jamboonsri was a PhD student in Plant Physiology)
    Authors in PSS Dept.: David F. Hildebrand Tim Phillips
    Li, R., K. Yu, Y. Wu, M. Tateno, T. Hatanaka, and D. Hildebrand*. 2012. Vernonia DGATs can complement the disrupted oil and protein metabolism in epoxygenase-expressing soybean seeds. Metabolic Engineering 14: 29-38.
    Wu, Y., R. Li, and D. Hildebrand. 2012. Biosynthesis and metabolic engineering palmitoleate production, and important contributor to human health. Progress in Lipid Research 51: 340-349.
    Adler, P.B., E.W. Seabloom, E.T. Borer, H. Hillebrand, Y. Hautier, A. Hector, W.S. Harpole, L.R. O’Halloran, J.B. Grace, T.M. Anderson, J.D. Bakker, L.A. Biederman, C.S. Brown, Y.M. Buckley, L.B. Calabrese, C. Chu, E.E. Cleland, S.L. Collins, K.L. Cottingham, M.J. Crawley, E.I. Damschen, K.F. Davies, N.M. DeCrappeo, P.A. Fay, J. Firn, P. Frater, E.I. Gasarch, D.S. Gruner, N. Hagenah, J. Hille Ris Lambers, H. Humphries, V.L. Jin, A.D. Kay, K.P. Kirkham, J.A. Klein, J.M.H. Knops, K.J. LaPierre, J.G. Lambrinos, W. Li, A.S. MacDougall, R.L. McCulley, et al. 2011. Productivity is a poor predictor of plant species richness. Science 333:1750-1753.
    Authors in PSS Dept.: David F. Hildebrand Rebecca McCulley
    Armstrong P.R., J.G. Tallada, C. Hurburgh, D.F. Hildebrand, and J.E. Specht. 2011. Development of single-seed near-infrared spectroscopic predictions of corn and soybean constituents using bulk reference values and mean spectra. Transactions of the American Society of Agricultural and Biological Engineers (ASABE) 54:1529-1535.
    Jamboonsri, W., T.D. Phillips, R.L. Geneve, J.P. Cahill, and D. Hildebrand. 2011. Extending the range of an ancient crop; a new ω3 source. Genetic Resources and Crop Evolution. Published online: doi: 101007/s10722-011-9673-x.
    Authors in PSS Dept.: David F. Hildebrand Tim Phillips
    Rao, S. and D. Hildebrand. 2009. Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene. Lipids 44:945-951.
    Hilker, B. L., Hirotada Fukushige, C. Hou, and David F. Hildebrand. 2008. Comparison of Bacillus monooxygenase genes for unique fatty acid production. Progress in Lipid Research 47:1-14.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Rao, S., M. Taha, and D. Hildebrand. 2008. Characteristics of high α-linolenic acid accumulation in seed oils. Lipids 43:749-755.
    Yu, K., R. Li, T. Hatanaka, and D. Hildebrand. 2008. Cloning and functional analysis of two type 1 diacylglycerol acyltransferases from Vernonia galamensis. Phytochemistry 69:1119-1127.
    Yu, K., C.T. McCracken Jr., and D.F. Hildebrand. 2007. Synthesis of sn-1,2-diacyl[U-14C] glycerol with high specific activity. pp. 6-10. IN: C. Benning, and J. Ohlrogge, ed. Current Advances in the Biochemistry and Cell Biology of Plant Lipids. Proceedings, 17th International Symposium on Plant Lipids. Aardvark Global Publishing Company LLC, Salt Lake City, Utah.
    Afitlhile, M.M., H. Fukushige, and D. Hildebrand. 2005. A defect in glyoxysomal fatty acid oxidation reduces jasmonic acid accumulation in Arabidopsis. Plant Physiology and Biochemistry 43:603-609.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Afitlhile, M.M., H. Fukushige, C. McCraken, and D. Hildebrand 2005. Allene oxide synthase and hydroperoxide lyase product accumulation in Artemisia species Plant Science 169:139-146.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Fukushige, H., and D.F. Hildebrand. 2005. A simple and efficient system for green note compound biosynthesis by use of certain lipoxygenase and hydroperoxide lyase sources Journal of Agricultural and Food Chemistry 53:6877-6882.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Fukushige, H., C. Wang, T.D. Simpson, H.W. Gardner, and D.F. Hildebrand. 2005. Purification and identification of linoleic acid hydroperoxides generated by soybean lipoxygenases 2 and 3. P Journal of Agricultural and Food Chemistry 53:5691-5694.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Fukushige, Hirotada, David F. Hilderbrand 2005. Watermelon (Citrullus lanatus) hydroperoxide lyase greatly increases C6 aldehyde formation in transgenic leaves. Journal of Agricultural and Food Chemistry 53:2046-2051.
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Hildebrand, D., and L. Mamadou. 2005. Genetically engineered oils. AOCS Press, Champaigh, ILL.
    Afitlhile, M.M., H. Fukushige and D. Hildebrand. 2004. Labeling of major plant lipids and jasmonic acid using [1-14C] lauric acid. Phytochemistry 65:2679-2684
    Authors in PSS Dept.: David F. Hildebrand Hirotada Fukushige
    Hatanaka, T., R. Shimizu, and D. Hildebrand. 2004. Expression of a Stokesia laevis epoxygenase gene. Phytochemistry.
    Hildebrand, D., K. Yu, C. McCracken, and S. Rao. 2004. Fatty acid changes. Biology, Utilization and Manipulation.

College Numbered Extension Publications