University of Kentucky College of Agriculture
 
 
 
LowellBush

Lowell P. Bush

Emeritus Faculty

 

Directions to University of Kentucky, Lexington, KYUniversity of Kentucky, PSS
Campus LocationPlant Science Building
1405 Veterans Drive (Office:315)
Lexington, KY 40546-0312
Phone(859) 218-0764
Fax(859) 257-7125
Emaillpbush@uky.edu

 

Speciality
tobacco and tall fescue alkaloids

Education
BA Macalester College, 1961
MS Iowa State University, 1963
PhD Iowa State University, 1964

Alkaloid metabolism in tobacco and in tall fescue infected by endophytic fungi. Demethylation of nicotine to nornicotine and subsequent tobacco specific N-nitrosamine formation, especially N-nitrosonornicotine during curing. Pyrrolizidine and ergot-like alkaloids from tall fescue and animal toxicosis.

Post-doctoral University of Minnesota 1964-1966
Faculty member of Dept of Agronomy, University of Kentucky 1966 to present
Fulbright Scholar to Ireland 1987

 

 

This person page last updated on 2012-10-04



Research/Teaching Publications

    Books and Book Chapters

    Bush, L.P., and F.F. Fannin. 2009. Alkaloids. Chapter 13, pp. 229-249. IN: H.A. Fribourg, D.B. Hannaway, and C.P. West, ed. Tall Fescue for the Twenty-First Century. Agronomy Monograph 53. American Society of Agronomy, Madison, Wis.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin
    Lowell P.Bush, 2008. Tobacco industry. pp. 991-996. IN: G. Goreham, ed. Encyclopedia of Rural America. Volume 2. Grey House Publishing, Millerton, N.Y.
    Bush, L.P., C.A. Roberts, and C. Schultz. 2007. Plant chemistry and antiquality components in forage. Chapter 33, pp. 509-528. IN: R.F. Barnes, C.J. Nelson, K.J. Moore, and M. Collins, ed. Forages: The Science of Grassland Agriculture, Vol. II. Blackwell Publishing, Ames, Iowa.
    Jack, A., N. Fannin, and L.P. Bush. 2007. Implications of reducing nornicotine accumulation in burley tobacco. pp. 39-91. IN: J. Jelesko, P. Nelson, and J. Wanna, ed. Recent Advances in Tobacco Science: Frontiers in Tobacco Biotechnology. Book series volume 33, Symposium proceedings, 61st meeting, Tobacco Science Research Conference, Charlotte, N.C.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin Anne Jack

    Refereed Journal Articles

    Cai B., and L. P. Bush. 2012. Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf. Journal of Agricultural and Food Chemistry. 60(46): 11586−11591. Published online: doi: 10.1021/jf303681u. (Bin Cai was a PhD student in Plant Physiology)
    Authors in PSS Dept.: Lowell P. Bush Bin Cai
    Cai, B., B. Siminszky, J. Chappell, R. E. Dewey, and L. P. Bush. 2012. Enantioselective demethylation of nicotine as a mechanism for variable nornicotine composition in tobacco leaf. The Journal of Biological Chemistry 287(51): 42804–42811. Published online: doi: 10.1074/jbc.M112.413807. (Bin Cai was a PhD student in Plant Physiology)
    Authors in PSS Dept.: Lowell P. Bush Joseph Chappell Bin Cai
    Foote, A. P., Harmon, D. L., Brown, K. R., Strickland*, J. R., Mcleod, K. R., Bush, L. P., and Klotz, J. L. 2012. Constriction of bovine vasculature by endophyte-infected tall fescue seed extract is similar to pure ergovaline. Journal of Animal Science 90: 1603-1609.
    Klotz, J. L., K. R. Brown, Y. Xue, J. C. Matthews, J. A. Boling, W. R. Burris, L. P. Bush, and J. R. Strickland. 2012. Alterations in serotonin receptor-induced contractility of bovine lateral saphenous vein in cattle grazing endophyte-infected tall fescue. Journal of Animal Science 90: 682-693.
    Koontz, A. F., L. P. Bush, J. L. Klotz, K. R. McLeod, F. N. Schrick, and D. L. Harmon. 2012. Evaluation of a ruminally dosed tall fescue seed extract as a model for fescue toxicosis in steers. Journal of Animal Science 90: 914-921.
    Lewis, R. S., R. G. Parker, D. A. Danehower, K. Andres, A. M. Jack*, D. S. Whitley, and L. P. Bush. 2012. Impact of Alleles at the Yellow Burley (Yb) Loci and Nitrogen Fertilization Rate on Nitrogen Utilization Efficiency and Tobacco-Specific Nitrosamine (TSNA) Formation in Air-Cured Tobacco. Journal of Food Agriculture and Environment 60(25): 6454-6461. Published online: doi: 10.1021/jf2053614.
    Authors in PSS Dept.: Lowell P. Bush Anne Jack
    Shi, H. Z., R. Y. Wang, L. P. Bush*, H. J. Yang, and F. F. Fannin. 2012. The relationships between TSNAs and their precursors in burley tobacco from different regions and varieties. Journal of Food Agriculture and Environment 10: 1048-1052.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin
    Brosi, G.B., R.L. McCulley, L.P. Bush, J.A. Nelson, A.T. Classen, and R.J. Norby. 2011. Effects of multiple climate change factors on the tall fescue—fungal endophyte symbiosis: Infection frequency and tissue chemistry. New Phytologist 189:797-805.
    Authors in PSS Dept.: Lowell P. Bush Jim Nelson Rebecca McCulley
    Brosi, GB, RL McCulley, LP Bush, JA Nelson, AT Classen, RJ Norby. 2011. Effects of multiple climate change factors on the tall fescue-fungal endophyte symbiosis: infection frequency and tissue chemistry. New Phytologist 189:797-805
    Authors in PSS Dept.: Lowell P. Bush Rebecca McCulley Jim Nelson
    Klotz, J.L., B.H. Kirch, G.E. Aiken, L.P. Bush, and J.R. Strickland. 2010. Contractile response of fescue-naive bovine lateral saphenous veins to increasing concentrations of tall fescue alkaloids. Journal of Animal Science 88(1):408-415. Published online: doi: 10.2527/jas.2009-2243.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Siegrist, J.A., R.L. McCulley, L.P. Bush, and T.D. Phillips. 2010. Alkaloids may not be responsible for endophyte-associated reductions in tall fescue decomposition rates. Functional Ecology 24(2):460-468. Published online: doi: 10:1111/j.1365-2435.2009.01649.x.
    Authors in PSS Dept.: Lowell P. Bush Rebecca McCulley Tim Phillips
    Aiken, G.E., J.R. Strickland, M.L. Looper, L.P. Bush, and F.N. Schrick. 2009. Hemodynamics are altered in caudal artery of beef heifers fed different ergot alkaloid concentrations. Journal of Animal Science 87:2142-2150.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Belesky, D.P., J.M. Ruckle, and L.P. Bush. 2009. Microsite conditions influence utritive value characteristics of a tall fescue cultivar devoid of, or infected with, a native or a novel nonergogenic endophyte. Environmental and Experimental Botany 67:284-292.
    Klotz, J.L., B.H. Kirch, G.E. Aiken, L.P. Bush, and J.R. Strickland. 2009. Bioaccumulation of ergovaline in bovine lateral saphenous veins in vitro. Journal of Animal Science 87:2437-2447.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Omacini, M., E.J. Chaneton, L. Bush, and C.M. Ghersa. 2009. A fungal endosymbiont affects host plant recruitment through seed- and littermediated mechanism. Functional Ecology 23:1148-1156.
    Siegrist, J.A., R.L. McCulley, L.P. Bush, and T.D. Phillips. 2009. Alkaloids may not be responsible for endophyte-associated reductions in tall fescue decomposition rates. Functional Ecology. Published online: doi:10.1111/j.1365-2435.2009.01649.x.
    Authors in PSS Dept.: Lowell P. Bush Rebecca McCulley Tim Phillips
    Klotz, J.L., B.H. Kirch, G.E. Aiken, L.P. Bush, and J.R. Strickland. 2008. Effects of selected combinations of tall fescue alkaloids on the vasoconstrictive capacity of fescue-naïve bovine lateral saphenous veins. Journal of Animal Scientist 86:1021-1028.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Lewis, R.S., A.M. Jack, J.W. Morris, V.M. Robert, L.B. Gaviliano, B. Siminszky, L P. Bush, A.J. Hayes, and R.E. Dewey. 2008. RNA interference (RNAi)-induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves. Plant Biotechnology Journal 6:346-354.
    Lowell P.Bush, 2008. Tobacco industry. pp. 991-996. IN: G. Goreham, ed. Encyclopedia of Rural America. Volume 2. Grey House Publishing, Millerton, N.Y.
    Aiken, G.E., B.H. Kirch, J.R. Strickland, L.P. Bush, M.L. Looper, and F.N. Schrick. 2007. Hemodynamic responses of the caudal artery to toxic tall fescue in beef heifers. Journal of Animal Science 85:2337-2345.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Fannin, F. F., D. Kubly, Y. Wang, and L.P. Bush. 2007. Epidemiological study with the mare and Neotyphodium coenophialum toxins. pp. 423-425. IN: A.J. Popay and E.R. Thom, ed. Proceedings, 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13. New Zealand Grassland Association, Christchurch, New Zealand, March 25-28.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin
    Klotz, J.L., B.H. Kirch, G.E. Aiken, L.P. Bush, B.C. Arrington, and J.R. Strickland. 2007. Assessment of vasoconstrictive capacity of tall fescue alkaloids using fescue naive lateral saphenous veins of crossbred heifer cattle. pp. 383-385. IN: A.J. Popay and E.R. Thom, ed. Proceedings, 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13. New Zealand Grassland Association, Christchurch, New Zealand, March 25-28.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken
    Klotz, J.L., L.P. Bush, D.L. Smit, W.D. Shafer, L.L. Smith, B.C. Arrington, and J.R. Strickland. 2007. Ergovaline-induced vasoconstriction in an isolated bovine lateral saphenous vein bioassay. Journal Animal Science 85:2330-2336.
    Krauss, J., S.A. Harri, L.P. Bush, R. Husi, L. Bigler, S.A. Power, and C.B. Muller. 2007. Effects of fertilizer, fungal endophytes, and plant cultivar on the performance of insect herbivores and their natural enemies. Functional Ecology 21:107-116.
    Krauss, J., S.A. Harri, L.P. Bush, S.A. Power, and C.B. Muller. 2007. Fungal grass endophytes, grass cultivars, nitrogen deposition, and the associations with colonising insects. pp. 53-57. IN: A.J. Popay and E.R. Thom, ed. 6th International Symposium on Fungal Endophytes of Grasses. Grassland Research and Practice Series 13. New Zealand Grassland Association, Christchurch, New Zealand, March 25-28.
    Ball, O.J.–P., Thomas A. Coudron, Brian A. Tapper, Elizabeth Davies, David Trently, Lowell P. Bush, Kimberly D. Gwinn, Alison J. Popay 2006. Importance of Host Plant Species, Neotyphodium Endophyte Isolate, and Alkaloids on Feeding by Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae Journal of Economic Entomology, Vol. 99, pp 1462-1473. Publication URL
    Gavilano, L.B.,N.P Coleman, L.E. Burnley, M.L. Bowman, E.N. Kalengamaliro, A Hayes, L.P. Bush and B. Siminszky. 2006. Genetic engineering of Nicotiana tabacum for reduced nornicotine content. Journal of Agricultural and Food Chemistry 54(24):9071-9078.
    Authors in PSS Dept.: Lowell P. Bush Balazs Siminszky Lily Gavilano
    Lily B. Gavilano, Nicholas P. Coleman, Leigh-Emma Burnley, Melissa L. Bowman, Newton E. Kalengamaliro, Alec Hayes, Lowell Bush and Balazs Siminszky* 2006. Genetic Engineering of Nicotiana Tabacum for Reduced Nornicotine Content. Journal of Agricultural and Food Chemistry. 54:9071-9078.
    Authors in PSS Dept.: Lowell P. Bush Balazs Siminszky Lily Gavilano
    Schultz, CL, SL Lodge-Ivey, LP Bush, AM Craig, JR Srickland 2006. Effects of initial and extended exposure to an endophyte-infected tall fescue seed diet on faecal and urinary excretion of ergovaline and lysergic acid in mature geldings New Zealand Veterinary Journal 54:178-184
    Bush, L.P. Tien C. (T.C.). 2005. Tso, Recipient of the 2005 Tobacco Science Research Conference Lifetime Achievement Award. Beitrage Tabakforsch International.
    Long, P.W., J.C. Henning and L.P. Bush. 2005. Ergovaline and ergovalinine and tall fescue content of pastures in central Kentucky. p. 309. IN: F.P. O’Mara et al., ed. Proceedings, 20th International Grassland Congress, Dublin, Ireland, June 26-July 1.
    Authors in PSS Dept.: Lowell P. Bush Jimmy Henning
    Schultz, C.L., S.L. Lodge-Ivey, A.M. Craig, J.R. Strickland, and L.P. Bush. 2005. The effects of exposure to endophyte-infected tall fescue seed on fecal and urine concentrations of ergovaline and lysergic acid in mature gelding horses. in F.P. O'Mara etal. ed. Proceedings 20th International Grassland Congress, Dublin, Ireland. June 26-July 1. p308
    Shi, H., L.P. Bush, and M. Krauss. 2005. Effect of nicotine to nornicotine conversion on myosmine and TSNA contents of burley tobacco. Tobacco Science and Technology 10:27-30.

    Peer-Reviewed Publications

    Bin Cai, Balazs Siminszky, Joseph Chappell, Ralph E. Dewey and Lowell P. Bush 2012. Enantioselective Demethylation of Nicotine as a Mechanism for Variable Nornicotine Composition in Tobacco Leaf Publication URL
    Authors in PSS Dept.: Lowell P. Bush Bin Cai
    Bin Cai, Lowell P.Bush 2012. Variable Nornicotine Enantiomeric Composition Caused by Nicotine Demethylase CYP82E4 in Tobacco Leaf Publication URL
    Authors in PSS Dept.: Lowell P. Bush Bin Cai

    Other Research Publications

    Brown, K.R., G.A. Anderson, K. Son, G.K. Rentfrow, L.P. Bush, J.L. Klotz, J.R. Strickland, J.A. Boling, and J.C. Matthews. 2008. Growing steers grazing high versus low endophyte (Neotyphodium coenophialum)-infected forages have reduced serum enzymes, increased hepatic glucogenic enzymes, and reduced liver and carcass tissue mass. Published online: doi:10.2527/jas.2008-1108. http://jas.fass.org/cgi/content/full.87/2/748.
    Burhan, W., F.F. Fannin, and L.P. Bush. 2008. Pyrrolizidine alkaloid accumulation in tall fescue during plant growth and development. Multifunctional Grasslands in a Changing World, Vol 1.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin
    Bush, L.P., X. Li, and F. F. Fannin. 2007. Tobaccospecific nitrosamines in air-cured tobacco. pp. 28-40. Proceedings, International Symposium on Tobacco. Henan Agricultural University, Zhengzhou, Henan, People’s Republic of China, Nov. 16-18.
    Authors in PSS Dept.: Lowell P. Bush Neil Fannin
    Jack, A., and L.P. Bush. 2007. Leaf contributions towards reduced-harm products. pp. 1-19. TabExpo Congress Papers, Paris, France, Nov. 26-29.
    Authors in PSS Dept.: Lowell P. Bush Anne Jack
    Klotz, J.L., B.H. Kirch, G.E. Aiken, J.R. Strickland, L.P. Bush, K.R. Brown, J.C. Matthews, and J.A. Boling. 2007. Vasoactivity of selected ergot alkaloids. SERA-IEG 8, Tall Fescue Toxicosis/Endophyte Workshop, Wildersville, Tenn., Oct. 14-16.
    Authors in PSS Dept.: Lowell P. Bush Glen Aiken